… to the membrane insertion behavior of melittin mostly from a computational aspect. Membrane
… were further made to understand the molecular mechanism of melittin interaction with cell …

… In this work, we use multiscale molecular dynamics simulations to investigate the melittin …
We choose six simulations to calculate the energies of LJ and electrostatic interactions. …

… action of the C-terminal melittin sequence through electrostatic interactions with the five basic
residues of … In solution, melittin molecules are monomeric and have random coil structure …

… inter-molecular cooperation; the probable reaction pathway and … In this work, the membrane
interaction process of melittin and … , the characteristic behaviors (eg membrane thinning and …

… over extended-time courses (6–24 hours), meaning that immediate cellular interactions …
, including antibody therapeutics, peptides and other small molecule therapeutics [2–4]. …

… on the molecular recognition of melittin, we further compared the interactions of melittin-WT/-…
the potency of melittin to interact and disrupt the eukaryotic cell membrane, including the …

… numbers of melittin molecules interacted with lipid membranes, melittin caused a strong
disturbance to the membranes’ … of interactions between melittin and PS-containing phospholipid …

… The following interactions between membranes and melittin were … the membrane leads to
the embedding of calcein molecules … melittin could work in a cooperative manner in membrane …

… peptide, as a testing molecule we demonstrated that even the … still mechanically perturb a
cell membrane by adsorption and … in membrane is crucial during the membrane interaction …

… 30%) and a positive charge (+ 2 to + 9) which lead to amphipathic conformations in interaction
with cell membranes. The AMPs bind to phospholipids' negatively charged head groups …