… on rats treated with phenolic acid revealed that a high dosage of caffeic acid was favorable
for bone anabolism, whereas a low dosage had detrimental effects on bone anabolism. …

… It is characterized by a reduction in bone mass, compromised bone microstructure,
heightened bone fragility, and an increased susceptibility to fractures. The dynamic imbalance …

… , and membrane receptors modulating cell-signal transduction cascade and specific
molecular pathways leading to bone anabolic effects and decreasing bone resorption [9,10]. In …

… significant increase in bone volume fraction and bone mineral density, and more trabecular
… promote bone formation, inhibit bone resorption, and effectively prevent loss of bone mass …

… The current study suggested that the combination of TA and PAM is a more effective
anabolic agent for promoting bone metabolism in hFOB 1.19 cells via upregulation of the …

… the exploitation of polyphenol properties from grape pomace extracts as complementary
active molecules for dental materials and devices for bone regeneration in periodontal defects. …

… status and in mineral tissue homeostasis mainly by promoting bone resorption [9–12].
Moreover, ROS act as signaling molecules in several signaling pathways in bone cells and …

… and stimulating effect in the bone regeneration process due to the pro-… bone signaling
pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone…

… Phytobiologics also influence the bone anabolic mechanisms through signaling pathways,
such as Wnt/β-catenin, Runx2, BMPs, ER, and insulin-like growth factor (IGF1) [Citation20]. …

… Bone mineralization is controlled by a dynamic and balanced mechanism, with bone formation
mediated by osteoblasts and bone resorption mediated by osteoclasts. However, under …