… The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing
diverse chemical stimuli to alter cell state- and are the largest class of drug targets. Their myriad …

G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–associated
molecules mediating signal transmission, and their involvement in key physiological …

… G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in
a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

… Heterotrimetic G proteins consist of four subfamilies (G s , G i/o , G q/11 , and G 12/13 ) that
mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding …

… G protein-coupled receptors (GPCRs) are members of the largest and most diverse group
of membrane receptors in eukaryotes. GPCRs account for 4% of human genes (Kooistra et al., …

… G-protein coupled receptors (GPCRs) control multiple physiological states by transducing
a multitude of extracellular stimuli into the cell via coupling to intra-cellular heterotrimeric G-…

… Recent studies have shown that G protein coupled receptors (GPCRs) show selective and
promiscuous coupling to different Gα protein subfamilies and yet the mechanisms of the range …

… The enormous sizes of adhesion G protein-coupled receptors (aGPCRs) go along with
complex genomic exon-intron architectures giving rise to multiple mRNA variants. There is a …

… Prominent among the many types of transmembrane receptors are G protein-coupled
receptors (GPCRs) [9–11]. In particular, class A (rhodopsin-like) GPCRs are the most abundant …

… receptor phosphorylation by G protein–coupled receptor kinases (GRKs) (59), followed by
phosphorylation-dependent binding of β-arrestins (60) ( Figure 1 ). While this process was …