… In agreement with previous findings, our simulation model demonstrated the CD36 mutations
found from our patients would destabilize the structure of CD36 protein, which may further …

… in the treatment of atypical hemolytic uremic syndrome (HUS). … Eculizumab efficacy was
monitored using serum hemolytic … the authors utilized statistical models using a propensity score …

… , the model was the most sensitive to the mixture cure model … The model considered adult
and paediatric treatment-naïve … (treatment [drug acquisition, administration], monitoring, …

… We propose a two-hit mechanism model leading to HUS. Indeed, in case 1, HUS unfolded …
-diseases-surveillance-report-2015.pdf). In comparison, atypical hemolytic uremic syndrome (…

… of the models with and without these variables. Overall performance of the model when neither
serum AST … A model using AST and ALT together did not improve the performance of the …

… nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) are well-…
Until then, close surveillance for signs and symptoms of recurrent TMA is recommended if …

… Treatment with eculizumab in Shiga toxin–associated haemolytic and uraemic syndrome
(STEC-… The timing of complement activity monitoring and the values of CAE before and after …

… These findings should be confirmed in more suitable and disease-relevant cell models with
cultured human endothelial cells. Nevertheless, they indicate that the p.367Arg FB mutant …

… Mean arterial pressure (MAP) derived from 24-hour ambulatory BP monitoring was … Methods:
Nephrin lacking the transmembrane domain (Nephmis) was used as a model of misfolded …

… drug monitoring of eculizumab in atypical haemolytic–uraemic syndrome patients. … A
population PK model was developed from these data in order to: (i) describe the relationship …