Trends in antihypertensive medication monotherapy and combination use among US adults, National Health and Nutrition Examination Survey 2005–2016

CG Derington, JB King, JS Herrick, D Shimbo… - …, 2020 - Am Heart Assoc
… represents a missed opportunity to lower BP and CVD risk. In conjunction with previous
evidence, 4–6 the current analysis suggests that to restore an upward trend in BP control rates, …

Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis

MA Suchard, MJ Schuemie, HM Krumholz, SC You… - The Lancet, 2019 - thelancet.com
… We report results comparing monotherapy drug classes from participating data sources … As
expected, we saw blunted estimates of differential effectiveness and risks between drug class

Effectiveness of two‐drug therapy versus monotherapy as initial regimen in hypertension: A propensity score‐matched cohort study in the UK Clinical Practice …

K Marinier, P Macouillard… - … and Drug Safety, 2019 - Wiley Online Library
… of antihypertensive drugs initiated as a two-drug combination versus monotherapy on BP
control and cardiovascular risk. … identified in primary care or through hospital admission.35 …

First‐line treatment of essential hypertension: a real‐world analysis across four antihypertensive treatment classes

M Stapff, S Hilderbrand - The Journal of Clinical Hypertension, 2019 - Wiley Online Library
… Treatment guidelines focus on individual risk factors like … health care organizations as
data sources stay anonymous. … mild hypertension due to the requirement of a monotherapy. …

Comprehensive comparative effectiveness and safety of first-line β-blocker monotherapy in hypertensive patients: a large-scale multicenter observational study

S Chan You, HM Krumholz, MA Suchard… - …, 2021 - Am Heart Assoc
… This study identified signals for most well-known adverse events of antihypertensives, such
as increased risk for bradycardia in β-blockers, angioedema or cough in ACE inhibitors, and …

Adherence to treatment by initial antihypertensive mono and combination therapies

F Rea, L Savaré, M Franchi, G Corrao… - … of Hypertension, 2021 - academic.oup.com
… The antihypertensive drugs prescribed in monotherapy … ) according to the hospital admission
and the drugs prescribed in … , the chance of being highly adherent to antihypertensive drug

Two-drug combinations as first-step antihypertensive treatment

G Mancia, F Rea, G Corrao, G Grassi - Circulation research, 2019 - Am Heart Assoc
… prescription of monotherapy or 2 antihypertensive drugs (B, … antihypertensive drug treatment,
the risk of hospitalization for hip … for a number of drug classes compared randomly selected …

The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients

RJ Shaw, D Mackay, JP Pell, S Padmanabhan… - … medicine, 2021 - cambridge.org
… a prescription for an antihypertensive drug outside their monotherapy class. Patients were
Monotherapy with major antihypertensive drug classes and risk of hospital admissions for …

Treatment and prescribing trends of antihypertensive drugs in 2.7 million UK primary care patients over 31 years: a population-based cohort study

J Rouette, EG McDonald, T Schuster, JM Brophy… - BMJ open, 2022 - bmjopen.bmj.com
… with hypertension, few studies have investigated the application … a first-line antihypertensive
drug in monotherapy before and after … . Persistence, adherence, and risk of discontinuation …

[HTML][HTML] Association of antihypertensive agents with the risk of in-hospital death in patients with Covid-19

L Chouchana, N Beeker, N Garcelon, B Rance… - Cardiovascular Drugs …, 2022 - Springer
Antihypertensive agent exposure has been identified in EHRs at admission of the hospital
stay for … exposure to the most frequent antihypertensive regimens, including monotherapies. …