The fusion of vital imaging information has turned into a primary issue for biomedical applications. In this paper, a new multi-modality medical image fusion method is proposed in the shearlet domain. In the proposed algorithm, input images are decomposed using Non-subsampled shearlet transform (NSST) to get low and high frequencies components. A novel procedure to decompose and combine the base layers and detail layers using the local extrema (LE) approach is used and fused using a Co-occurrence filter (CoF) in low-frequency components. In high-frequency components, an edge-preserving image fusion strategy is performed using sum modified Laplacian (SML) to combine the high-frequency coefficients. The experimental outcomes and comparative analysis are performed over the Multi-modal medical image dataset using proposed and existing methods. It is exhibited through test outcomes and assessments that the proposed technique beats the cutting-edge fusion strategies concerning edge preservation in subjective and objective assessment criteria.