… Multifocal prostate cancers typically have one dominant focus, or index tumor, and one or
more smaller and secondary malignant foci [22]. One study reported that 88% of radical …

… Prostate cancer is a multifocal disease since at diagnosis primary tumors contain multiple …
molecular levels have identified tumor heterogeneity as a key biological property of prostate …

Context Studies characterising genomic changes in prostate cancer (PCa) during natural
progression have greatly increased our understanding of the disease. A better understanding …

… the biological basis for clinical variability among different lesions, we sought to comprehensively
characterize the heterogeneity of somatic gene mutations in multifocal prostate cancer. …

… tumor foci in different anatomical zones of the prostate is … The impact of tumor multifocality in
PCa prognosis has been … MF and UF prostatic carcinomas may be biologically different, with …

… To determine the prevalence of multiparametric magnetic resonance imaging (mpMRI)-detected
and targeted biopsy-confirmed multifocal and unifocal prostate cancer (PCa) among …

… ) is critical in the management of males with prostate cancer (PC). Over the past decades,
a … been shown to be associated with a poor prognosis in both breast and prostate cancer (88). …

… Prostate cancer has a … prostate cancer patient care and in the research field. The power of
deep sequencing has provided cistromic and transcriptomic knowledge of prostate cancer that …

… Multifocal prostate cancer is known to have early divergence between foci, but there is
often … , especially locally advanced disease, is biologically similar to metastatic, castrate-resistant …

… multifocal nature of prostate cancer, we have investigated how the performance of the TCGA
… is affected by intra-patient heterogeneity in a series of multifocal primary prostate cancer. …