… Increased DNA methylation level in the promoter of this gene was identified in leukocytes
of patients with multiple sclerosis [Citation48]. In RR-MS patients, hypermethylation of …

… risk individuals with RIS, it is very possible that treatment administration for RIS will be approved
in the future. The presence of high-risk … the development of the concept of MS prodrome. …

… The concept of a prodromal period for MS—a period prior to … multiple sclerosis usually
presents between 20 and 40 years … Obesity is a known risk factor for multiple sclerosis (MS). Both …

… Multiple sclerosis (MS) is a potentially debilitating disease … risk factors have been implicated
as potential triggers and/or … A systemic prodrome has been described in patients with MS in …

… For health professionals, my work showed support for early screening as well as routine
screening for possible risk factors and comorbidities. Health professionals may wish to focus …

… D pathways, other sun-induced immune-associated pathways, … )D levels are independent
risk factors for MS, suggesting a … onset is referred to as the “prodromal phase” of MS [75]. …

… the potential association between medical history and the development of multiple sclerosis
(… factors act as protective agents or risk factors for MS. This study aimed to evaluate the MS …

Epstein-Barr virus (EBV) is the infectious agent that shows the strongest association with
multiple sclerosis (MS). EBV is a ubiquitous double stranded DNA herpes virus that establishes …

… , risk factors associated with transitioning to multiple sclerosis, … pointed towards a likely
prodromal phase that precedes a … of the afferent visual pathway in patients with demyelinating …

… of inflammatory pathways leading to depression (68, 69). However, a causal relationship
between DMTs, especially T and B-cell depleting therapies, and the risk of depression remains …