Somatic mutation profiles as molecular classifiers of ulcerative colitisassociated colorectal cancer

S Mäki‐Nevala, S Ukwattage… - … Journal of Cancer, 2021 - Wiley Online Library
… MMR, CIMP, BRAF Val600Glu and KRAS mutation statuses are widely used molecular
classifiers of CRC, where MSI is associated with favorable prognosis and BRAF mutation with …

[HTML][HTML] Molecular characterization of ulcerative colitis-associated colorectal carcinomas

D Hirsch, J Hardt, C Sauer, K Heselmeyer-Hadded… - Modern Pathology, 2021 - Elsevier
… Patients with ulcerative colitis (UC) are at an increased risk of developing and dying from
colorectal cancer (CRC), which increases as a function of the extent, duration, and severity of …

Targeted mutational analysis of inflammatory bowel disease–associated colorectal cancers

L Alpert, L Yassan, R Poon, S Kadri, N Niu, SA Patil… - Human pathology, 2019 - Elsevier
… disease (CD) than in those with ulcerative colitis (UC) [3], [8]. … BRAF mutation. The third
case exhibited isolated MSH6 loss, which suggests that a germline mutation in the MSH6 gene

Morphological, immunohistochemical and molecular features of inflammatory bowel disease associated colorectal carcinoma and associated mucosal lesions–single …

K Kamarádová, H Vošmiková, K Rozkošová… - … -Research and Practice, 2019 - Elsevier
IBD) – ulcerative colitis (UC) and Crohn’s disease (CD) have an elevated risk of developing
colorectal carcinoma … for KRAS, NRAS and BRAF gene mutation were performed in the …

Genomic landscape of early-stage colorectal neoplasia developing from the ulcerative colitis mucosa in the Japanese population

K Matsumoto, Y Urabe, S Oka, K Inagaki… - Inflammatory Bowel …, 2021 - academic.oup.com
ulcerative colitis (UC) have an increased risk for developing colorectal cancer (CRC), known
as colitis-associated cancer … that serrated colorectal lesions with KRAS and BRAF mutations

[HTML][HTML] Identification of genes critical for inducing ulcerative colitis and exploring their tumorigenic potential in human colorectal carcinoma

R Patra, AK Dey, S Mukherjee - PloS One, 2023 - journals.plos.org
… KRAS and NRAS are mutated in 40% of cases of CRC, resulting in conformational changes
inhibiting the GTPase activity of RAS-GAP [38]. The mutation in BRAF increases the kinase …

[HTML][HTML] Molecular mechanisms in colitis-associated colorectal cancer

RW Zhou, N Harpaz, SH Itzkowitz, RE Parsons - Oncogenesis, 2023 - nature.com
ulcerative colitis to be associated with increased risk of advanced colorectal neoplasia
compared to just left-sided ulcerative … to be mutually exclusive with mutations in BRAF (Table 1). …

[HTML][HTML] Colitis and colorectal tumors should be further explored and differentiated

DH Xu, B Zhou, ZP Li, LP He… - World Journal of …, 2022 - ncbi.nlm.nih.gov
… These all suggest that colorectal tumors are not only caused by ulcerative colitis, … colitis
and colorectal tumors. Keywords: Colorectal cancer, Nicotine, p53, Tobacco, Ulcerative colitis

[HTML][HTML] Correlation between KRAS, NRAS and BRAF mutations and tumor localizations in patients with primary and metastatic colorectal cancer

A Bożyk, P Krawczyk, K Reszka… - Archives of Medical …, 2022 - ncbi.nlm.nih.gov
… We examined the frequency of mutations in the KRAS, NRAS and BRAF genes in 500 …
disease, as known as Crohn disease and ulcerative colitis. Authors, among risk factors, also …

Evolutionary history of human colitis-associated colorectal cancer

AM Baker, W Cross, K Curtius, I Al Bakir, CHR Choi… - Gut, 2019 - gut.bmj.com
… UC09 harboured a BRAF V600E mutation, UC02 was confirmed as MSI using fragment …
. Forty-Year analysis of colonoscopic surveillance program for neoplasia in ulcerative colitis: …