… To determine whether Gata2 is mutated in APLs arising spontaneously in Ctsg-PML-RARA
mice, we performed exome sequencing of 13 APL samples with paired normal (tail DNA) …

… ), suggesting that WT1 mutations may have similar biologic … reflect a tumor suppressor activity,
since inactivating mutations … the ability of Wt1 mutations to co-operate with PML-RARA in a …

… PML is mainly involved in tumor suppression and genomic … More recently, point mutations
in the PML-RARA fusion gene … suggested that mutations occurred in the two moieties of PML-…

… Acute myeloid leukemia is mainly characterized by a … most relevant mutations affecting tumor
suppressor genes that … regulator PML in PML-RARα positive AMLs and NPM1 mutations via …

… transcription of RARa target genes and disrupting PML-NBs. … involving homeostasis and
tumor suppression mechanisms, … combination of gene mutation with gene expression analysis …

… Dysregulation of PML, a significant tumor suppressor is linked with cancers of different …
We further generated an ERβ mutant construct (Δ144-225) that lacks the ERβ DNA binding …

… PML is located in chromosome 15q24, and PML together with … to perform its function of tumor
suppression and genomic stability … that PML or RARA mutation impaired the binding of PML-…

… repressor in acute promyelocytic leukemia (APL). Here, we provide rich evidence of how
PML/… We further used PML/RARα-F158E (with the mutation in the RBCC domain impairing …

… vitro models has shown that mutations in the B2 domain of the PML protein, mediate arsenic
… , which results in the expression of the Promyelocytic leukemia (PML)–retinoic acid receptor-…

… of RARAα with the promyelocytic leukemia (PML) gene in the … , additional genetic aberrations
such as mutations in FLT3, … The other FLT3 aberration is a point mutation in the region …