… inhibits sodium potassium adenosine triphosphatase (Na + /K + -ATPase) and in the
myocardium it increases the intracellular level of sodium and calcium ions in the myocytes thus …

… study suggests digoxin may adversely affect renal function in … warranted to elucidate digoxin's
renal effects in CHF patients. … The demographic distribution of the sample population was …

… Renal function is an important index for digoxin dose … Typical values for clearance and volume
of distribution were 2.67 … Digoxin enhanced myocardial contractility and improved ejection …

… Multivariable Cox proportional hazards and sub-distribution … events or renal function decline
in advanced CKD patients. … heart rate and increases myocardial contractility by inhibiting …

… As the volume of distribution is smaller in patients with severe renal failure that normal subjects…
intracellular calcium in myocardial cells, patients with renal dysfunction are more prone to …

… inhibits sodium potassium adenosine triphosphatase (Na+/K+-ATPase) and in the myocardium
it increases the intracellular level … Distribution of renal function at baseline in patients on …

… and myocardial contractility and modulates neurohormonal abnormalities in patients with
heart … Digoxin has a large volume distribution (4–8 L/kg) and is distributed mainly in skeletal …

… on the myocardial cells and on the cardiac conduction system 2 . … renal function but it may
be doubled in renal impairment or … CHF, which decreased the volume of distribution of digoxin. …

… of digoxin with younger age and preserved renal function may be explained by the renal
excretion of digoxin, … amongst the elderly and those with renal impairment. More severe HF was …

… digoxin pharmacokinetics, the volume of distribution is large, … myocardial abnormalities in
the absence of coronary artery … blood digoxin concentration due to worsening renal function …