Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy
… of NAD + content in the golden retriever muscular dystrophy (… Global poly(ADP-ribosylation)
is increased in striated … A Representative immunoblots showing total PARylated protein …
is increased in striated … A Representative immunoblots showing total PARylated protein …
Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle
DW Frederick, AV McDougal, M Semenas, J Vappiani… - Skeletal Muscle, 2020 - Springer
… muscular dystrophy (DMD) is a progressive muscle wasting … characterizing the global
metabolome of MDX muscle following … However, both NAD-modulating strategies employed in our …
metabolome of MDX muscle following … However, both NAD-modulating strategies employed in our …
Maintenance of NAD+ homeostasis in skeletal muscle during aging and exercise
… it a potential supplement to counter NAD+ deficiency and protect … to observe increases in
NAD+ levels or limb muscle functional … SIRT1 activity and lower global protein acetylation after …
NAD+ levels or limb muscle functional … SIRT1 activity and lower global protein acetylation after …
Need for NAD+: Focus on Striated Muscle Laminopathies
D Cardoso, A Muchir - Cells, 2020 - mdpi.com
… The covalent modification of proteins by PARylation … NAD + levels with Niagen administration
in a mice model of Duchenne muscular dystrophy improved cardiac and skeletal functions […
in a mice model of Duchenne muscular dystrophy improved cardiac and skeletal functions […
NAD+ Therapeutics and Skeletal Muscle Adaptation to Exercise in Humans
… that NAD + therapeutics do not alter skeletal muscle metabolism or improve athletic … in
mouse models of mitochondrial myopathy [49, 50] and Duchenne muscular dystrophy [51]…
mouse models of mitochondrial myopathy [49, 50] and Duchenne muscular dystrophy [51]…
The Role of PARylation in Skeletal Muscle During the Development of Cancer Cachexia
A Nik-Akhtar - 2023 - ruor.uottawa.ca
… the way have the power to transform our understanding of the world and our place within it.
… Given that NAD+ is a substrate for PARylation, the process of PARylation has a significant …
… Given that NAD+ is a substrate for PARylation, the process of PARylation has a significant …
Role of PGC-1α in the Mitochondrial NAD+ Pool in Metabolic Diseases
JH Koh, JY Kim - International Journal of Molecular Sciences, 2021 - mdpi.com
… , NAD + boosting can be one of the strategies to improve … the role of the SIRTs–PGC-1α
pathway in increasing NAD + … PARPs regulate poly ADP-ribosylation (PARylation), which is …
pathway in increasing NAD + … PARPs regulate poly ADP-ribosylation (PARylation), which is …
[HTML][HTML] A systems-approach to NAD+ restoration
N Conlon, D Ford - Biochemical pharmacology, 2022 - Elsevier
… NAD+ in the muscle of both aged and muscular dystrophy (… a single NAD+ molecule, excessive
PARylation represents a … to decrease global proteome acetylation and improve glucose …
PARylation represents a … to decrease global proteome acetylation and improve glucose …
[HTML][HTML] NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
… features of the aging muscle that can be ameliorated by NAD … paired with perturbed cellular
proteostasis in skeletal muscle … chronic muscle conditions, including muscular dystrophies. …
proteostasis in skeletal muscle … chronic muscle conditions, including muscular dystrophies. …
[HTML][HTML] Potential Therapeutic Interventions Targeting NAD+ Metabolism for ALS
S Lundt, S Ding - Cells, 2024 - mdpi.com
… Excessive addition of PAR polymers (PARylation), results in a form of cell death … in NAD +
[48]. PARP activity has also been connected to multiple diseases, including muscular dystrophy…
[48]. PARP activity has also been connected to multiple diseases, including muscular dystrophy…