Targeted and proteome-wide analysis of metabolite–protein interactions
… As a complementary approach, reactivity-based chemical … lysine, which can reveal ‘ligandable’
hot spots in proteins with … al [53] showed that NHS esters primarily target lysine residues …
hot spots in proteins with … al [53] showed that NHS esters primarily target lysine residues …
Reimagining druggability using chemoproteomic platforms
JN Spradlin, E Zhang, DK Nomura - Accounts of Chemical …, 2021 - ACS Publications
… proteome by using reactivity-based chemical probes and advanced … probes that react
with amino acid hotspots within proteins to map proteome-wide reactive and ligandable …
with amino acid hotspots within proteins to map proteome-wide reactive and ligandable …
Fragment-based covalent ligand discovery
… being deployed on a proteome-wide scale thereby expanding … 4B) as versatile ABPP probes
to profile ligandable protein … to estimate warhead reactivity based on quantum mechanics (…
to profile ligandable protein … to estimate warhead reactivity based on quantum mechanics (…
Profiling the proteome-wide selectivity of diverse electrophiles
… probes to monitor a total of nine different amino acids as well as the N-terminus proteome-wide. …
Global profiling of lysine reactivity and ligandability in the human proteome. Nat. Chem. …
Global profiling of lysine reactivity and ligandability in the human proteome. Nat. Chem. …
Lysine-targeted inhibitors and chemoproteomic probes
A Cuesta, J Taunton - Annual Review of Biochemistry, 2019 - annualreviews.org
… and ligandability of lysines on a proteome-wide scale (41, 42), we argue that the amine-reactive
probes deployed thus far have captured only a small fraction of the ligandable lysinome, …
probes deployed thus far have captured only a small fraction of the ligandable lysinome, …
Development of lysine-reactive covalent inhibitors and chemoproteomic probes
AA Cuesta - 2019 - escholarship.org
… and ligandability of lysines on a proteome-wide scale,41,42 we argue that the amine-reactive
probes deployed thus far have captured only a small fraction of the 'ligandable lysinome', …
probes deployed thus far have captured only a small fraction of the 'ligandable lysinome', …
Precision targeting of endogenous epidermal growth factor receptor (EGFR) by structurally aligned dual-modifier labeling
I de Jesus Salazar-Estrada, KS Kamath… - ACS Pharmacology & …, 2022 - ACS Publications
… by chemical probes is used for proteome-wide profiling of … As such, the reactivity-based
probe with only the NHS ester … This is consistent with prior observations that NHS esters can be …
probe with only the NHS ester … This is consistent with prior observations that NHS esters can be …
[图书][B] Redefining Druggability Using Chemoproteomic Platforms
CC Ward - 2020 - search.proquest.com
… , we show that NHS-esters are viable chemoproteomic probes, … ) as a versatile reactivity-based
probe for mapping the reactivity … for mapping the reactivity of proteome-wide accessible …
probe for mapping the reactivity … for mapping the reactivity of proteome-wide accessible …
Utility of chemical probes for mass spectrometry based chemical proteomics
B Bajrami, JG Martin, DS Johnson - Advances in Chemical Proteomics, 2022 - Elsevier
… , ABPs/reactivity-based probes and photoaffinity probes will … approaches to map proteome-wide
reactive cysteine and lysine … hotspots within proteins to explore potential ligandable sites …
reactive cysteine and lysine … hotspots within proteins to explore potential ligandable sites …
A proteome-wide atlas of lysine-reactive chemistry
… proteome-wide by leveraging reactive chemical probes and … the ligandable lysine proteome,
and thus constitute versatile ‘… We also show here how integrating these ligandability maps …
and thus constitute versatile ‘… We also show here how integrating these ligandability maps …