… Increase the efficacy of liposome-based nanovaccine against Acinetobacter baumannii-associated pneumonia in immunocompetent and immunocompromised mice

MA Khan, KS Allemailem, H Maswadeh, H Younus - Molecules, 2022 - mdpi.com
… induced strong humoral and cell-mediated immune responses in vaccinated mice. The …
baumannii helps bacteria to thrive under hostile conditions and also contributes to multidrug …

[HTML][HTML] The leaves of the seasoning plant Litsea cubeba inhibit the NLRP3 inflammasome and ameliorate dextran sulfate sodium-induced colitis in mice

WT Wong, CH Wu, LH Li, DY Hung, HW Chiu… - Frontiers in …, 2022 - frontiersin.org
… Staphylococcus aureus and Acinetobacter baumannii (6, 7). L. … We found that MLE reduced
ATP-mediated IL-1β expression … NLRP3 activator stimulation leads to the release of reactive …

Interleukin 1β receptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1

R Piacentini, C Grassi - Neural Regeneration Research - journals.lww.com
… that NLRP3 inflammasome mediates IL-1β production in several models on … in immune
cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in mice. …

Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo

…, K Caution, A Abu Khweek, K Hamilton, A Badr… - Scientific reports, 2021 - nature.com
… cenocepacia without altering mice survival. This study … the contribution of GSDMD pore
formation or cell lysis to … thailandensis and Acinetobacter baumannii infection, IL-1β ' secretion in …

SERPINB1-mediated checkpoint of inflammatory caspase activation

YJ Choi, S Kim, Y Choi, TB Nielsen, J Yan, A Lu… - Nature …, 2019 - nature.com
… (for example, it processes pro-interleukin (pro-IL-1β) into … virulent clinical isolate of
Acinetobacter baumannii called ‘HUMC1’ … For NLRP3 inflammasome activation, THP1 cells were …

[HTML][HTML] Enhanced activity of Ellagic acid in lipid nanoparticles (EA-liposomes) against Acinetobacter baumannii in immunosuppressed mice

KS Allemailem - Saudi Journal of Biological Sciences, 2023 - Elsevier
… Liposome-mediated site specific targeting may reduce the dose … The biofilm helps bacteria
to develop the multidrug resistance… also rejuvenates the immune cells in CYP-injected mice. …

Host immunity and cellular responses to bacterial outer membrane vesicles

V Tiku, MW Tan - Trends in Immunology, 2021 - cell.com
… ; blocking these entry routes using inhibitors leads to … delivery of LPS from OMVs into
mouse peritoneal macrophages [ … to promote pathogenesis of Acinetobacter baumannii. …

Pyroptosis: a new regulating mechanism in cardiovascular disease

N Ji, Z Qi, Y Wang, X Yang, Z Yan, M Li… - … of inflammation …, 2021 - Taylor & Francis
NLRP3, and the structurally altered NLRP3 inflammasome … of NLRP3 leads to a concomitant
high activation of NLRP3 … Caspase-1 mediates the cleavage of interleukin- (IL-1β) …

The Pseudomonas aeruginosa Type III secretion system exoenzyme effector ExoU induces mitochondrial damage in a murine bone marrow-derived macrophage …

KS Hardy, AN Tuckey, NA Housley… - … and Immunity, 2022 - Am Soc Microbiol
… , interleukin (IL-1β), to suppress activation of inflammation… to acknowledge possible
contributions from other cytosolic … Interestingly, the NLRP3 inflammasome has been previously …

[HTML][HTML] Antibiotics as immunomodulators: a potential pharmacologic approach for ARDS treatment

A Sauer, K Peukert, C Putensen… - European Respiratory …, 2021 - Eur Respiratory Soc
leads to influx of protein-rich pulmonary oedema fluid and … the inflammatory response is
the NLRP3 inflammasome which … -induced lung injury in mice by inhibiting inflammasome-…