Long COVID-19 and the heart: is cardiac mitochondria the missing link?

X Chang, NI Ismail, A Rahman, D Xu… - Antioxidants & Redox …, 2023 - liebertpub.com
… burst-induced mitochondrial oxidative stress damages good … regulators of MAVS signaling
(NLRX1, NDFIP2), and the … induces oxidative stress and caspase-independent apoptosis

Raising the 'good'oxidants for immune protection

A Dumas, UG Knaus - Frontiers in immunology, 2021 - frontiersin.org
… associated with oxidative damage and tissue injury, ROS … for the complex between thioredoxin
and apoptosis signal-regulating … The NLR family member NLRX1 cannot only interact with …

Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions

AA Otunla, K Shanmugarajah, AH Davies… - Frontiers in …, 2024 - frontiersin.org
NLRX1 plays a protective role in ischemic AKI, with NLRX1 KO leading to more severe
mitochondrial damage, oxidative stress and renal epithelial cell apoptosis in an IRI mouse model (…

High-Density Lipoproteins at the Interface between the NLRP3 Inflammasome and Myocardial Infarction

HRP Carmo, I Bonilha, J Barreto, M Tognolini… - International Journal of …, 2024 - mdpi.com
… , heightened oxidative stress, increased activity of proteolytic … cell death pathways,
encompassing apoptosis, necroptosis, and … or a dampening of SAA’s pro-inflammatory activities in …

Nucleotide-binding oligomerization domain-like receptor X1 restricts porcine reproductive and respiratory syndrome virus-2 replication by interacting with viral Nsp9

H Jing, T Song, S Cao, Y Sun, J Wang, W Dong… - Virus research, 2019 - Elsevier
… Thus, our study establishes the role of NLRX1 as a new host … For example, NLRX1 prevented
IAV-induced macrophage apoptosis. … by the mitochondrial Nod-like family member NLRX1

[HTML][HTML] Mitophagy and cGAS–STING crosstalk in neuroinflammation

X Zhou, J Wang, L Yu, G Qiao, D Qin, BYK Law… - … Pharmaceutica Sinica B, 2024 - Elsevier
mitochondria can lead to a wide range of cellular problems, including impaired energy
metabolism, increased oxidative stress, and activation of apoptotic … , mitochondria function

Improving Sperm Cryopreservation With Type III Antifreeze Protein: Proteomic Profiling of Cynomolgus Macaque (Macaca fascicularis) Sperm

B Chen, S Wang, BM Inglis, H Ding, A Suo… - Frontiers in …, 2021 - frontiersin.org
… on cynomolgus macaque sperm function. The functions of selected … , mitochondrial function,
heat/oxidative stress, apoptosis, … to protect cells from oxidative stress and cell apoptosis. The …

[图书][B] NLRX1 and TFEB in metabolism and renal diseases

L Kors - 2020 - dare.uva.nl
… effect of NLRX1 on mitochondrial oxidative metabolism that … function of NLRX1, namely the
regulation of mitochondrial … found that NLRX1 is critical for proper kidney disease control. In …

Tubular cell glucose metabolism shift during acute and chronic injuries

A Faivre, T Verissimo, H Auwerx, D Legouis… - Frontiers in …, 2021 - frontiersin.org
… NADPH and glutathione, thus decreasing oxidative stress (48, 94)… the inhibition of
TP53-inducible glycolysis and apoptosis … (NLRX1) was shown to be detrimental (95). Inhibition of …

[HTML][HTML] Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts

L Reiter, N Niehoff, D Weiland, D Helbig, SA Eming… - Matrix Biology, 2024 - Elsevier
… altered ratios of proliferation to apoptosis might be causative for … We suggest that mtDNA
mutations dampen mitochondrial … upon oxidative stress-induced lysyl oxidase activity can be …