The impact of intrauterine growth restriction and prematurity on nephron endowment

MR Sutherland, MJ Black - Nature Reviews Nephrology, 2023 - nature.com
renal filtration surface area, and therefore diminished renal … susceptibility to the later
development of kidney disease. … capillary growth compared with that of unventilated control sheep

Renal morphology and glomerular capillarisation in young adult sheep born moderately preterm

MR Sutherland, W Malik, VB Nguyen, V Tran… - … Origins of Health and …, 2021 - cambridge.org
… length, surface area and total renal filtration surface area in the … length and surface area,
and the morphology of the kidneys, in … on nephron endowment in the preterm baboon kidney. …

Structural and functional changes in the kidney caused by adverse fetal and neonatal environments

M Awazu - Molecular Biology Reports, 2022 - Springer
growth restriction (IUGR), the followingdevelopment was reported to be altered in preterm
sheep. Thus glomerular capillary length, surface area, and total kidney filtration surface area

Physiology and pathophysiology of compensatory adaptations of a solitary functioning kidney

Z McArdle, MF Schreuder, KM Moritz… - Frontiers in …, 2020 - frontiersin.org
… and an increase in single nephron glomerular filtration rate (… suggest that the total nephron
endowment in congenital SFK … In sheep with congenital SFK, the renal responses to systemic …

[HTML][HTML] Low nephron endowment increases susceptibility to renal stress and chronic kidney disease

PI Good, L Li, HA Hurst, IS Herrera, K Xu, M Rao… - JCI insight, 2023 - ncbi.nlm.nih.gov
… the single-nephron glomerular filtration rate (GFR). These … While glomerular surface area
increased between 2 and 6 … long-term renal adverse effects following neonatal AKI in the …

Programming of renal development and chronic disease in adult life

ER Lumbers, Y Kandasamy, SJ Delforce… - Frontiers in …, 2020 - frontiersin.org
… between 90 and 120 mL/min/1.73 m 2 body surface area. … Thus, oligonephropathy caused
by fetal growth restriction or in … in the development of hypertension in young sheep whose …

Clinical consequences of developmental programming of low nephron number

VA Luyckx, BM Brenner - The Anatomical Record, 2020 - Wiley Online Library
growth restriction are associated with reduced nephronsheep, congenital or surgical loss
of nephrons during fetal … In contrast, kidney volume related to body surface area (BSA) at age …

[HTML][HTML] Brenner & Rector's the Kidney

V Luyckx, K Skorecki, PA Marsden, GM Chertow - 2019 - doctorlib.info
… in nephron number and whole kidney glomerular surface area … rats or fetal uninephrectomy
in sheep, that is, loss of nephrons at a … in utero in fetuses subjected to growth restriction. [84] …

[PDF][PDF] Strategies to prevent glomerular hyperfiltration injury in congenital solitary kidneys

Z McArdle - 2021 - repository.ubn.ru.nl
… by removal of a kidney from the sheep fetus at gestation day 100… pressure and increase in
the filtering surface area.These … These findings also suggest that the total nephron endowment

Nephron number and its determinants: a 2020 update

JR Charlton, EJ Baldelomar, DM Hyatt, KM Bennett - Pediatric Nephrology, 2021 - Springer
… , excluding those with intrauterine growth restriction and … a lower nephron endowment
may be at higher risk for kidney … fundamental understanding of kidney filtration, removed from …