Neuromuscular diseases and their cardiac manifestations under the spectrum of cardiovascular imaging
GM Alexandridis, ED Pagourelias, N Fragakis… - Heart Failure …, 2022 - Springer
GM Alexandridis, ED Pagourelias, N Fragakis, M Kyriazi, E Vargiami, D Zafeiriou…
Heart Failure Reviews, 2022•SpringerNeuromuscular diseases (NMDs) include a broad spectrum of disorders that affect motor
unit in every possible site, extending from the cell body of peripheral nerves to the muscle.
The different lesion sites make this group of inherited disorders difficult to diagnose. Many
NMDs, especially those involving skeletal muscles, can present significant cardiovascular
complications, ranging from rhythm disturbances to the development of dilated or
hypertrophic cardiomyopathy. Heart disease represents a major cause of morbidity and …
unit in every possible site, extending from the cell body of peripheral nerves to the muscle.
The different lesion sites make this group of inherited disorders difficult to diagnose. Many
NMDs, especially those involving skeletal muscles, can present significant cardiovascular
complications, ranging from rhythm disturbances to the development of dilated or
hypertrophic cardiomyopathy. Heart disease represents a major cause of morbidity and …
Abstract
Neuromuscular diseases (NMDs) include a broad spectrum of disorders that affect motor unit in every possible site, extending from the cell body of peripheral nerves to the muscle. The different lesion sites make this group of inherited disorders difficult to diagnose. Many NMDs, especially those involving skeletal muscles, can present significant cardiovascular complications, ranging from rhythm disturbances to the development of dilated or hypertrophic cardiomyopathy. Heart disease represents a major cause of morbidity and mortality among NMD patients, underlining the vital need for further familiarization with the pathogenesis and assessment of cardiac involvement. Cardiovascular imaging is the cornerstone for the evaluation of heart disorders in NMDs, with conventional echocardiography still offering a portable, affordable, and easily accessible solution. Meanwhile, newer echocardiographic techniques such as speckle tracking imaging in combination with cardiac magnetic resonance add new insights into further substrate characterization. The purpose of this review is to offer a brief presentation of the main NMDs and their cardiovascular complications, as well as the presentation of data that highlight the importance of cardiovascular imaging in early diagnosis, monitoring, and prognosis of these patients. Lastly, the authors provide a simple guide about which clinical features, imaging findings, and follow-up plan to adopt in each myopathic disorder.
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