Tachykinins: neuropeptides that are ancient, diverse, widespread and functionally pleiotropic

DR Nässel, M Zandawala, T Kawada… - Frontiers in …, 2019 - frontiersin.org
… In the following we will discuss additional roles of TKs in sea … “tachykinin in insects” yields
about 200 hits and therefore our … activity, we already see an increase in studies of invertebrate …

Novel biology of tachykinins in gonadotropin-releasing hormone secretion

S Leon, VM Navarro - Seminars in Reproductive Medicine, 2019 - thieme-connect.com
tachykinins are a fundamental piece,[7] as well as peripheral … The distribution of the
tachykinin receptors in hypothalamic … remaining question regarding SP and NKA relates to their

Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts

A Campo, S Dufour, K Rousseau - Frontiers in Endocrinology, 2022 - frontiersin.org
… several new tachykinin peptides, with widespread peripheral … TAC for tachykinin peptides
and tac for tachykinin genes and … A recent review addresses the question whether the KNDy …

Neurokinin receptor antagonism: a patent review (2014-present)

M Muñoz, R Coveñas - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
peripheral and central nervous systems, a distribution even … As tachykinin peptides and
their receptors are involved in … Both of these are key questions that must be answered and …

Tachykinins and kisspeptins in the regulation of human male fertility

V Blasco, FM Pinto, C González-Ravina… - Journal of Clinical …, 2019 - mdpi.com
peripheral reproductive roles of the tachykinin family and the … the roles of these peptide
families and increase our knowledge … Problems such as spermatogenesis defects or altered …

Tachykinin antagonists in asthma and inflammation

CA Maggi - Proinflammatory and Antiinflammatory Peptides, 2020 - taylorfrancis.com
… and peripheral nervous system has been reviewed recently ( 11 )… The obvious question of
whether granulocytes express TK … vivo effects of tachykinins on immune cell function in guinea-…

The place of tachykinin NK2 receptor antagonists in the treatment diarrhea-predominant irritable bowel syndrome

A Szymaszkiewicz, A Malkiewicz… - … of Physiology and …, 2019 - publicum.umed.lodz.pl
… in Western countries and it is still increasing (1). Based on the … In this review, we focused
on the role of tachykinins in … in the enteric nervous system, on the intrinsic peripheral afferent …

The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch

TD Sheahan, CA Warwick, LG Fanien… - Journal of …, 2020 - Soc Neuroscience
… suggest a role for NK1R interneurons in itch and extend our … , ending with the mouse raising
its head away from its body. Head … The results of this study address two important questions

The neurokinins: peptidomimetic ligand design and therapeutic applications

C Gadais, S Ballet - Current Medicinal Chemistry, 2020 - ingentaconnect.com
… CNS) and peripheral tissues, their discovery rapidly promoted … binding and activation of
tachykinin receptors (wherein X is an … the first discovered member of the mammalian tachykinins, …

Structures of neurokinin 1 receptor in complex with Gq and Gs proteins reveal substance P binding mode and unique activation features

…, Y Waltenspühl, J Schöppe, O Medalia, A Plückthun - Science …, 2021 - science.org
… , ranging from the central and peripheral nervous system (5, 6) to … C-terminal amidation is
a central feature of tachykinins … charged lysine, as found in NK 3 R, increases affinity of NKB, …