… of unique roles of nNOSμ and nNOSβ in regulating muscle structure, strength and fatigue …
of nNOS and GC isoforms facilitates the creation of spatially and functionally distinct NO-cGMP …

… This disruption of subcellular localization of NOS isoforms, ie, changes in spatial
localization of nNOS from its normal position (ie, SR) to the sarcolemma, may contribute to the …

… Three isoforms of NOS have been described in humans, … The isoforms of NOS have distinct
physiological roles within … and nNOS regulate arterial blood flow (with each isoform having …

… is a physiological mechanism to regulate protein function. On … confined by its high reactivity,
which shorts dramatically NO … ), being the former the isoform α of nNOS expressed in the …

… levels to finely regulate NO homeostasis. In the cardiovascular system … NO synthesis consists
of a reaction catalyzed by a family of NOS isoforms (EC 1.14.13.39) featuring the oxidation …

… The NOS1 and NOS3 isoforms are constitutively expressed … , occurring in a spatially confined
manner and in signaling … exerting positive effects on heart muscle and regulating L-type …

… (NOS) isoform performs are not yet fully understood. … In other words, the effects of NO will
depend on the spatial … the role of local NO production by nNOS in regulating coronary flow and, …

… As negative controls, metoprolol minimally affected cardiac … subtypes and phosphodiesterase
isoforms to modulate cardiac … the PM, which is spatially segregated from NOS1 enriched in …

… (NOS) exists in three isoforms, all of which generate NO and L… These spatial constraints
suggest effects coupled to nearby … to reduced fatty acid synthesis, increased fatty acid oxidation, …

… NOS is regulated by other molecules such as NADPH and calmodulin (CaM) [24,25]. …
Although all three NOS isoforms produce NO for S-nitrosylation, each isoform can mediate …