… basic and translational research of these complex transcription factors. … Gli1, Gli2, and
Gli3 play non-redundant roles in T-cell maturation in the thymus and B-cell development in the …

… of transcription factor glioma-associated oncogene (Gli1, Gli2… profoundly affects the later
stages of thymocyte development. … during the inflammatory phase of multiple sclerosis and …

… were deleted from thymocytes, from the DN2 stage onwards, by … Here, we have identified
two novel important functions for … of the transcription factors Klf2, Runx1 and Gli1 and the Wnt …

… In fact, GLI transcription factors control the expression of a … that thymocyte development
was blocked at the DN3 stage [… two pathways could upregulate GLI1/GLI2 expression levels …

… In this thesis, I describe two transcriptional regulators of … In the second study, we identify the
transcription factor GLI-similar 2 … (NAC) strongly reduced ROS levels in thymocytes, lessened …

… Foxa2 is also expressed in developing T-cells in the thymus, … and WT Th2 cultures expressed
higher levels of Foxa2, we … for the Hh-responsive transcription factors Gli1 and Gli2, and …

… of numerous cells at a series of developmental stages from … the adult Gli1-deficient and
embryonic Gli2-deficient thymus … that Ihh acts upon Gli1 transcription factors during definitive …

… While the guiding transcription factors and effector molecules of … into Gli activator (GliA) and
Gli repressor (GliR) transcription … roles of Hedgehog during T cell development in the thymus, …

… that involve a dynamic association between Gli transcription factors, the final effectors of Hh
… T-cell development even if they play a non-redundant role in orchestrating early thymocyte …

… of GLI1 abrogation on early stages of human development … by GLI1, GLI2, and GLI3
transcription factors and plays several … GLI1 and GLI2 transcription factors bind the six GBS in the …