… the noradrenaline release that would in turn contribute to the … pain generator in chronic
conditions. Selective destruction of noradrenergic neurons appears to dampen neuropathic pain …

… In addition, considering that central sensitization, which was related to SDH microglia and
astrocytes [52], contributes to chronic pain including NP, we hypothesized that NE acted on …

… The noradrenergic locus coeruleus nucleus is an important station in both the ascending and
descending pain … We demonstrate that neuropathic pain increases the nociceptive evoked-…

… (LC), the principal brain site of noradrenaline synthesis, is targeted by several endogenous
… pathway is thought to contribute to the intrinsic excitability of LC neurons and regulate c-fos …

… Neuropathic pain induces anxio-depressive behaviors in rodents and changes in the
activity of LC noradrenergic neurons might contribute to that. It was shown that sciatic …

… -control inhibitory system nucleus implicated in descending modulation of pain through …
noradrenergic neurons and might contribute to pain control. Here we evaluated the contribution …

… in a rat model of neuropathic pain (chronic constriction injury), … plasticity of noradrenergic
locus coeruleus neurons relative … The asymmetric contribution of locus coeruleus modules was …

… pain, unmasking a descending facilitation noradrenergic pathway to the DRt. This activation
might contribute to spinal sensitization during neuropathic pain… that LC neurons projecting to …

… the descending noradrenergic system from the locus coeruleus (… neuropathic pain turns
into chronic pain, noradrenergic … of duloxetine lead to increase in noradrenaline levels in the …

… locus coeruleus on non-coerulean, discrete noradrenergic cell group(s). We implemented
locus coeruleus … present study may help to elucidate the origins of chronic pain where the LC, …