… Huntington’s disease is caused by an abnormally … of function in the mutant huntingtin (mHTT)
protein. There are currently no disease-modifying therapies available, but approaches that …

… Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms. …

… expansion in the huntingtin (HTT) gene, which encodes huntingtin protein (HTT). … Huntington’s
disease, we sought to inhibit HTT expression and thus directly target the primary disease …

… Row 2 represents the common genotype of individuals with Huntington disease (HD) … the
Huntington gene (HTT), which are estimated to have less than 50% of normal HTT function and …

… This article describes and discusses new potential disease-modifying therapies for Huntington’s
disease that are currently in human clinical trials as well as promising new therapies in …

… for the development of disease-modifying … the function of the wild-type huntingtin protein
through non-allele-selective compared with allele-selective approaches targeting the disease-…

… An attractive alternative approach is gene therapy using viral vectors containing the
BDNF gene, which allows for the constant and local production of the protein by the desired …

… exon 1 of the gene coding for huntingtin, placed in the short arm of … disease are unclear
and complex. Here, we review some of the currently known functions of the wild-type huntingtin …

… approaches include targeting the mutant huntingtin (mHTT) … role in other inherited and
neurological disorders. In this review, we aim to discuss current therapeutic research approaches …

… Huntington disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide
repeat expansion in the huntingtin (HTT) gene. Therapeutics that lower HTT have shown …