… saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in …

H Zhong, H Wu, H Bai, M Wang, J Wen, J Gong… - … and alternative medicine, 2019 - Springer
… ) signaling pathway in anterior cruciate ligament fibroblasts [17… PNS promoted primary
mouse hepatocyte proliferation via … Additionally, Notoginsenoside R1 exerts protective effects …

Phospholipase Cγ2 signalling contributes to the haemostatic effect of Notoginsenoside Ft1

Y Liu, T Liu, J Zhao, T He, H Chen… - Journal of Pharmacy …, 2019 - academic.oup.com
… on the effect of Notoginsenoside Ft1, a saponin with effect in promoting platelet aggregation.
Ft1 in promoting platelet aggregation, coagulation, angiogenesis and fibroblast proliferation

A Novel Biochemical Study of Anti-Dermal Fibroblast Replicative Senescence Potential of Panax Notoginseng Oligosaccharides

L Zhai, X Xu, J Liu, C Jing, X Yang, D Zhao… - Frontiers in …, 2021 - frontiersin.org
… natural skin aging by promoting fibroblast proliferative activity. … PNO treatment could indirectly
promote expression of CDK4, … NIH-3T3 cells via activation of the MAPK signaling pathway. …

The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing

X Zhou, Y Guo, K Yang, P Liu, J Wang - Journal of Ethnopharmacology, 2022 - Elsevier
Notoginsenoside Ft1 (Ft1), isolated from Panax … dermal fibroblast-adult (HDF-a), Ft1
promotes cell proliferation and collagen production through the PI3K/Akt/mTOR signaling pathway. …

Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury via Regulating PI3K/AKT Inhibited HIF-1α/VEGF Signaling Pathway

W Xie, P Zhou, M Qu, Z Dai, X Zhang… - Frontiers in …, 2020 - frontiersin.org
… the HIF-1α/VEGF signal pathway that exert marked effects on … Such as, notoginsenoside Ft1
was reported to enhance … an anoxic environment, thus promoting angiogenesis in conditions …

An update on the potential application of herbal medicine in promoting angiogenesis

J Li, R Li, X Wu, C Zheng, PHT Shiu… - Frontiers in …, 2022 - frontiersin.org
… In human dermal fibroblasts, notoginsenoside Ft1 increases cell proliferation and collagen
production via the PI3K/Akt/mechanistic target of the rapamycin (mTOR) signaling pathway. …

Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury via Regulating PI3K/AKT Inhibited HIF-1a/VEGF Signaling Pathway

W Xie, P Zhou, M Qu, Z Dai, X Zhang… - … A Feasible Approach …, 2021 - books.google.com
Notoginsenoside Ft1 Promotes Fibroblast Proliferation via PI3K/Akt/mTOR Signaling
Pathway and Benefits Wound Healing in Genetically Diabetic Mice. J. Pharmacol. …

[HTML][HTML] Bovine collagen oligopeptides accelerate wound healing by promoting fibroblast migration via PI3K/Akt/mTOR signaling pathway

L Bao, X Cai, M Zhang, Y Xiao, J Jin, T Qin… - Journal of Functional …, 2022 - Elsevier
… , 2016) found that notoginsenoside could accelerate diabetic wound healing and promote
fibroblast proliferation via PI3K/Akt/mTOR signaling pathway. A significant increase of the …

Botanical drugs in traditional Chinese medicine with wound healing properties

S Ning, J Zang, B Zhang, X Feng, F Qiu - Frontiers in pharmacology, 2022 - frontiersin.org
… , which will promote the proliferation of fibroblasts and endothelial cells. … fibroblast proliferation
via the activation of EGFR and its downstream ERK/CREB and PI3K/AKT/mTOR pathways

Natural herbal medicine as a treatment strategy for myocardial infarction through the regulation of angiogenesis

M Zhang, Y Song, W Xu, L Zhang… - Evidence‐Based …, 2022 - Wiley Online Library
… and weakening the ability of fibroblasts to strongly stimulate … VEGF through the PI3K/Akt/mTOR
pathway, thereby showing … Notoginsenoside Ft1 promotes angiogenesis through HIF-1α-…