… of antiproliferative activity of somatostatin analogues (SSAs) … limitations, recently, a novel
chimeric compound named TBR-… be a new molecule with relevant perspectives in the therapy of …

… in the administration of somatostatin analogs, both “cold”, … We also explore future perspectives
for SSTRs and SSAs in … Dopastatin, a novel chimeric analog with dual binding ability …

… Proof of pharmacology of BIM23B065 was shown by a reduction in GH, IGF-1, and PRL
concentrations in healthy male volunteers, supporting activity of the somatostatin analog and …

… For these reasons, a new generation chimeric agonist for SST 2 /SST 5 /D2R (BIM-065),
has … clinical use of this chimeric molecule. Somatostatin receptor expression and medical …

… Both octreotide and lanreotide (LAN), 2 somatostatin analogs (SSAs) with high affinity for
SST 2 and moderate activity for SST 5 , have shown an inhibitory effect in vitro in controlling …

… Dimerization is a novel frontier in the regulation of the activity of GPCRs. In fact, this receptor
family activity is modulated by homo-dimerization or hetero-dimerization, the latter possibly …

Somatostatin receptors (SSTRs) play versatile roles in inhibiting the secretion of multiple
hormones such as growth hormone and thyroid-stimulating hormone, and thus are considered …

… is, somatostatin analogs (SSAs) or dopamine-agonists (DA). Thus, novel, chimeric somatostatin/…
Conclusions: Our results unveil a robust antitumoral effect in vitro of the novel chimeric …

… In conclusion, our study, the first to evaluate the effect of a novel somatostatin receptor 5-preferring
ligand, shows that HTL0030310 can restrain hormone synthesis and secretion in …

… somatostatin receptors and somatostatin analogs as well as radiolabeled somatostatin
analogs are … We developed a second-generation chimeric antigen receptor (CAR) construct …