Polyadenylation and nuclear export of mRNAs

M Stewart - Journal of Biological Chemistry, 2019 - ASBMB
… mRNA nuclear export and how it is integrated into the nuclear phase of the gene expression
pathway. Nuclear export … , such as proteins and RNAs, between the cytoplasmic and nuclear

New progresses of circular RNA biology: from nuclear export to degradation

M Zhou, MS Xiao, Z Li, C Huang - RNA biology, 2021 - Taylor & Francis
… Once produced in the nucleus, the majority of circular RNAs are exported to the cytoplasm …
RNAs and highlight the recent advances in our understanding of circular RNA nuclear export

Mechanisms of nuclear mRNA export: A structural perspective

Y Xie, Y Ren - Traffic, 2019 - Wiley Online Library
… reduces the nuclear export of CTE-RNA in vivo, … ) RNA export. One hypothesis is that the
higher-order NXF1•NXT1 assembly may facilitate nuclear export of a subset of structured RNAs, …

Gene architecture and sequence composition underpin selective dependency of nuclear export of long RNAs on NXF1 and the TREX complex

B Zuckerman, M Ron, M Mikl, E Segal, I Ulitsky - Molecular Cell, 2020 - cell.com
export of virtually all polyadenylated RNAs. Here, we depleted different proteins that act in
nuclear export in human cells and quantified the transcriptome-wide consequences on RNA

Mechanisms of long noncoding RNA nuclear retention

CJ Guo, G Xu, LL Chen - Trends in biochemical sciences, 2020 - cell.com
… RMRP (RNA component of mitochondrial RNA-processing endoribonuclease) is localized
… the nuclear DNA. RMRP binds to HuR (human antigen R) in the nucleus and is exported into …

The nuclear export protein XPO1—from biology to targeted therapy

AS Azmi, MH Uddin, RM Mohammad - Nature reviews Clinical oncology, 2021 - nature.com
… The main physiological function of exportin 1 (XPO1) is the export of proteins and small
nuclear RNAs from the nucleus to the cytoplasm. XPO1 overexpression leads to greater levels of …

The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs

PJ Hsu, H Shi, AC Zhu, Z Lu, N Miller, BM Edens… - Journal of Biological …, 2019 - ASBMB
… may affect the nuclear export of m 6 A-modified RNA targets. … FMRP facilitates the nuclear
export of RNA transcripts, but … using nascent RNA from the whole-cell rather than nuclear or …

Targeting of nucleo‑cytoplasmic transport factor exportin 1 in malignancy

S Özdaş, İ Canatar - Medicine International, 2022 - spandidos-publications.com
nuclear‑cytoplasmic transport of protein, ribosomal RNA and certain required mRNAs for
ribosomal biogenesis. Furthermore, XPO1‑mediated nuclear export is … ‑mediated nuclear export

Inhibitors of nuclear transport

DA Jans, AJ Martin, KM Wagstaff - Current opinion in cell biology, 2019 - Elsevier
… was later shown to be a nuclear export inhibitor specifically targeting EXP1 and in … nuclear
export of various proteins, including signalling molecules such as mitogen activated protein

Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export

E Kneuss, M Munafò, EL Eastwood… - Genes & …, 2019 - genesdev.cshlp.org
export mediated by nuclear export factor 1 (Nxf1). Although UAP56, a component of the
transcription and export … Quantification of RNA-FISH was performed by counting nuclear and …