Characterizing the immune response to myocardial infarction in pigs

F Schnitter, F Stangl, E Noeske, M Bille… - Basic Research in …, 2024 - Springer
… that it might be a site of emergency myelopoiesis after MI in pigs, as previously shown in
mice. We thus provide a first description of the immune response to MI in pigs, and our results …

Preclinical models of myocardial infarction: from mechanism to translation

TP Martin, EA MacDonald… - British Journal of …, 2022 - Wiley Online Library
… early following MI such as cell death, reperfusion injury, inflammatory/immune responses,
fetal … The drug target itself can be species specific, for example, an enzyme active site. Multiple …

Guidelines for in vivo mouse models of myocardial infarction

ML Lindsey, KR Brunt, JA Kirk… - American Journal …, 2021 - journals.physiology.org
… expression in the left ventricle of mice following myocardial infarction. Am J Physiol Heart Circ
… Exogenous ubiquitin reduces inflammatory response and preserves myocardial function 3 …

[HTML][HTML] CpG postconditioning after reperfused myocardial infarction is associated with modulated inflammation, less apoptosis, and better left ventricular function

GD Duerr, S Wu, ML Schneider… - American Journal …, 2020 - journals.physiology.org
… and less collagen deposition after myocardial infarction (MI). A … mice. These data emphasize
the importance of an adequately orchestrated inflammatory response for optimal myocardial

… , remodeling and inflammation following myocardial ischemia–reperfusion injury or unreperfused myocardial infarction in hypercholesterolemic APOE* 3-Leiden mice

NJ Pluijmert, CI Bart, WH Bax, PHA Quax, DE Atsma - Scientific reports, 2020 - nature.com
… To unravel the systemic inflammatory response following … studies already reported significant
differences at other time points 32,… the inflammatory response independently of myocardial

Validation of diagnostic criteria and histopathological characterization of cardiac rupture in the mouse model of nonreperfused myocardial infarction

A Hanna, AV Shinde… - American Journal of …, 2020 - journals.physiology.org
… in mice dying after myocardial infarction … mice reflected overactive inflammatory responses
in myeloid cells, we compared cytokine and chemokine gene expression in sorted myocardial

Experimental animal models of coronary microvascular dysfunction

O Sorop, J van de Wouw, S Chandler… - Cardiovascular …, 2020 - academic.oup.com
… There are significant intrinsic differences between rodents … by species-specific activity of
thyroid hormones. Humans, … in DM dogs, acting to maintain CBF during increased myocardial

[HTML][HTML] Post-ischemic myocardial inflammatory response: a complex and dynamic process susceptible to immunomodulatory therapies

NJ Pluijmert, DE Atsma, PHA Quax - Frontiers in Cardiovascular …, 2021 - frontiersin.org
… HMGB1, the best characterized danger signal, is a key initiator of inflammatory injury following
myocardial ischemia controlled by action mechanisms involving TLRs (22, 23) and RAGEs…

Macrophages in myocardial infarction

A Kubota, NG Frangogiannis - American Journal of …, 2022 - journals.physiology.org
… elderly subjects suffering myocardial infarction. … inflammatory responses after myocardial
injury (219). Thus, in elderly subjects with myocardial infarction acute inhibition of inflammatory

Measuring inflammation in the entire myocardium in a canine model of myocardial infarction with hybrid PET/MRI

B Wilk - 2021 - search.proquest.com
… Background: After myocardial infarction (MI), fibrosis and an ongoing dysregulated inflammatory
response are associated with adverse cardiac remodeling. Fluorodeoxyglucose (FDG) …