Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction

E Dookun, A Walaszczyk, R Redgrave, P Palmowski… - bioRxiv, 2020 - biorxiv.org
… and adverse remodeling following cardiac ischemia-reperfusion. We also establish that
post-IRI senescent cells play a considerable role in the inflammatory response. Subsequently, …

Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart

S Huang, B Chen, Y Su, L Alex, C Humeres… - Journal of molecular and …, 2019 - Elsevier
… In order to examine whether myofibroblast-specific Smad2 loss affects scar remodeling
following myocardial infarction, we performed systematic analysis of morphometric parameters …

Pericytes in the infarcted heart

L Alex, NG Frangogiannis - Vascular Biology, 2019 - vb.bioscientifica.com
Following myocardial infarction, sudden loss of up to a billion … , activating an intense
inflammatory response that serves to … differences between studies, species-specific properties of …

Fibroblasts in the infarcted, remodeling, and failing heart

C Humeres, NG Frangogiannis - JACC: Basic to Translational Science, 2019 - jacc.org
… Neurohumoral pathways are critically implicated in regulation of fibroblast function following
myocardial infarction. Potent activation of the renin-angiotensin-aldosterone system in …

Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury

Y Wu, H Liu, X Wang - Life Sciences, 2021 - Elsevier
… The exaggerated inflammatory response mediates a series of interactions between … role
in the inflammatory process of myocardial I/R injury [29]. The triggered inflammatory signaling …

The role of Smad signaling cascades in cardiac fibrosis

A Hanna, C Humeres, NG Frangogiannis - Cellular signalling, 2021 - Elsevier
… role after myocardial infarction, excessive, unrestrained or dysregulated myocardial ECM …
overactive or dysregulated myocardial Smad-dependent fibrogenic responses are critical …

Nuclear imaging of post-infarction inflammation in ischemic cardiac diseases-new radiotracers for potential clinical applications

BJ Krenning, K der Heiden, DJ Duncker… - Current …, 2021 - ingentaconnect.com
… They conclude that “It will be important to establish a clear connection between the initial
inflammatory response after myocardial infarction and subsequent cognitive decline. Follow-up …

The potential actions of angiotensin‐converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases

T Qaradakhi, LK Gadanec… - Clinical and …, 2020 - Wiley Online Library
… further evidence for species-specific differences in the adverse … dysfunction post-myocardial
infarction.47 However, during … factor, reducing inflammatory responses.67 Treatment with …

Macrophages in ischemic heart failure: Yesterday, today, and tomorrow

D Liu, W Yan, J Huang, J Zhao, H Kilby… - Cardiology …, 2021 - mednexus.org
… mediators of the inflammatory response to myocardial injury. One study using different mouse
models of cardiac tissue damage (acute MI or reperfused myocardial injury) demonstrates …

… iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and …

CX Ge, MX Xu, YT Qin, TT Gu, DS Lou, Q Li… - Free Radical Biology …, 2019 - Elsevier
… could be developed to prevent myocardial inflammation and lipid deposition, consequently
… -expression exhibited severer inflammatory response and TG accumulation in comparison to …