Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction
E Dookun, A Walaszczyk, R Redgrave, P Palmowski… - bioRxiv, 2020 - biorxiv.org
… and adverse remodeling following cardiac ischemia-reperfusion. We also establish that
post-IRI senescent cells play a considerable role in the inflammatory response. Subsequently, …
post-IRI senescent cells play a considerable role in the inflammatory response. Subsequently, …
Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart
… In order to examine whether myofibroblast-specific Smad2 loss affects scar remodeling
following myocardial infarction, we performed systematic analysis of morphometric parameters …
following myocardial infarction, we performed systematic analysis of morphometric parameters …
Pericytes in the infarcted heart
L Alex, NG Frangogiannis - Vascular Biology, 2019 - vb.bioscientifica.com
… Following myocardial infarction, sudden loss of up to a billion … , activating an intense
inflammatory response that serves to … differences between studies, species-specific properties of …
inflammatory response that serves to … differences between studies, species-specific properties of …
Fibroblasts in the infarcted, remodeling, and failing heart
C Humeres, NG Frangogiannis - JACC: Basic to Translational Science, 2019 - jacc.org
… Neurohumoral pathways are critically implicated in regulation of fibroblast function following
myocardial infarction. Potent activation of the renin-angiotensin-aldosterone system in …
myocardial infarction. Potent activation of the renin-angiotensin-aldosterone system in …
Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury
Y Wu, H Liu, X Wang - Life Sciences, 2021 - Elsevier
… The exaggerated inflammatory response mediates a series of interactions between … role
in the inflammatory process of myocardial I/R injury [29]. The triggered inflammatory signaling …
in the inflammatory process of myocardial I/R injury [29]. The triggered inflammatory signaling …
The role of Smad signaling cascades in cardiac fibrosis
… role after myocardial infarction, excessive, unrestrained or dysregulated myocardial ECM …
overactive or dysregulated myocardial Smad-dependent fibrogenic responses are critical …
overactive or dysregulated myocardial Smad-dependent fibrogenic responses are critical …
Nuclear imaging of post-infarction inflammation in ischemic cardiac diseases-new radiotracers for potential clinical applications
BJ Krenning, K der Heiden, DJ Duncker… - Current …, 2021 - ingentaconnect.com
… They conclude that “It will be important to establish a clear connection between the initial
inflammatory response after myocardial infarction and subsequent cognitive decline. Follow-up …
inflammatory response after myocardial infarction and subsequent cognitive decline. Follow-up …
The potential actions of angiotensin‐converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases
T Qaradakhi, LK Gadanec… - Clinical and …, 2020 - Wiley Online Library
… further evidence for species-specific differences in the adverse … dysfunction post-myocardial
infarction.47 However, during … factor, reducing inflammatory responses.67 Treatment with …
infarction.47 However, during … factor, reducing inflammatory responses.67 Treatment with …
Macrophages in ischemic heart failure: Yesterday, today, and tomorrow
D Liu, W Yan, J Huang, J Zhao, H Kilby… - Cardiology …, 2021 - mednexus.org
… mediators of the inflammatory response to myocardial injury. One study using different mouse
models of cardiac tissue damage (acute MI or reperfused myocardial injury) demonstrates …
models of cardiac tissue damage (acute MI or reperfused myocardial injury) demonstrates …
… iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and …
… could be developed to prevent myocardial inflammation and lipid deposition, consequently
… -expression exhibited severer inflammatory response and TG accumulation in comparison to …
… -expression exhibited severer inflammatory response and TG accumulation in comparison to …