… iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and …

CX Ge, MX Xu, YT Qin, TT Gu, DS Lou, Q Li… - Free Radical Biology …, 2019 - Elsevier
… could be developed to prevent myocardial inflammation and lipid deposition, consequently
… -expression exhibited severer inflammatory response and TG accumulation in comparison to …

[HTML][HTML] Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

X Yin, X Yin, X Pan, J Zhang, X Fan, J Li… - Frontiers in …, 2023 - frontiersin.org
… on different immune cell populations, cytokines, chemokines and growth factors to improve
mechanistic understanding of immune responses. … the process of immune response after MI …

[HTML][HTML] Protein alterations in cardiac ischemia/reperfusion revealed by spatial-omics

STP Mezger, AMA Mingels, M Soulié… - International journal of …, 2022 - mdpi.com
… for coagulation and immune response proteins. Interestingly, … changes already after 15 min
while the myocardium appeared … This analysis revealed 11 m/z species-specific for the infarct …

[HTML][HTML] Animal models in allogenic solid organ transplantation

N Wenzel, R Blasczyk, C Figueiredo - Transplantology, 2021 - mdpi.com
… innate immune response, resulting in sterile inflammation and … many species-specific
differences between the mouse and … after that short distance, they pass through the myocardium

Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

M Gawałko, A Saljic, N Li, I Abu-Taha… - Cardiovascular …, 2023 - academic.oup.com
… We discuss the distinct effects of key secreted adipokines from different adipose tissue depots
… Epicardial fat lies between the visceral pericardium and myocardium, whereas paracardial …

Immune-mediated mechanisms

U Hofmann, S Frantz… - The ESC Textbook of …, 2024 - books.google.com
… the diseased myocardium elicit an immune response, including both innate and adaptive …
mice and dogs: species-specific differences in the inflammatory response following myocardial

[HTML][HTML] Heart failure relapses in response to acute stresses–role of immunological and inflammatory pathways

L Hasselbach, J Weidner, A Elsässer… - Frontiers in …, 2022 - frontiersin.org
… IL-1β is upregulated in animal models of HF of different etiologies (22, 23). The knockdown
… a reduced inflammatory response and less fibrosis after myocardial infarction in mice (24). …

From pediatrics to geriatrics: mechanisms of heart failure across the life-course

KC Woulfe, DR Bruns - Journal of molecular and cellular cardiology, 2019 - Elsevier
… that there is a species-specific time frame for cardiomyocyte maturity… This hypertrophic
response is accompanied by myocardial … with attenuated inflammatory responses, chronic post-MI …

[HTML][HTML] … training alleviates cardiac fibrosis through increasing fibroblast growth factor 21 and regulating TGF-β1-Smad2/3-MMP2/9 signaling in mice with myocardial …

Y Ma, Y Kuang, W Bo, Q Liang, W Zhu, M Cai… - International Journal of …, 2021 - mdpi.com
… Exercise training has been reported to alleviate cardiac fibrosis and ameliorate heart
dysfunction after myocardial infarction (MI), but the molecular mechanism is still not fully clarified. …

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …

KE Odening, AM Gomez, D Dobrev, L Fabritz… - EP …, 2021 - academic.oup.com
dogs (∼60–80 bpm). Accordingly, AP duration is also different between species, largely
due to important species-specific differences in repolarizing ion currents/channels (Figure 2). …