Targeting the metabolic rewiring in pancreatic cancer and its tumor microenvironment

K Yamamoto, D Iwadate, H Kato, Y Nakai, K Tateishi… - Cancers, 2022 - mdpi.com
… manner, dictated by oncogenic KRAS signaling and shaped in close interaction with the host
cells in the tumor microenvironment. … In an RAS-driven cancer model in D. melanogaster, …

Oncogenic KRAS-driven metabolic reprogramming in pancreatic cancer cells utilizes cytokines from the tumor microenvironment

P Dey, J Li, J Zhang, S Chaurasiya, A Strom, H Wang… - Cancer discovery, 2020 - AACR
… Type II cytokines, secreted by Th2 cells in the tumor microenvironment, can stimulate cancer
… in the early and advanced tumor microenvironment enables cooperative protumorigenic …

Role of the tumor microenvironment in cancer hallmarks and targeted therapy

R Naser, I Fakhoury, A El-Fouani… - International …, 2023 - spandidos-publications.com
… : Pro-inflammatory M1 and anti-inflammatory M2 (45). … These cells can rewire their metabolism
to maintain sufficient ATP … Metabolic reprogramming in the TME is driven by oncogenic

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

SA Kerk, T Papagiannakopoulos, YM Shah… - … Reviews Cancer, 2021 - nature.com
… disparate metabolic networks regulated by oncogenic mutant … and the role of the tumour
microenvironment. Furthermore, we … , and the complexity of RAS signalling still presents a …

Colorectal cancer: Metabolic interactions reshape the tumor microenvironment

J Chen, H Zhu, Y Yin, S Jia, X Luo - … Acta (BBA)-Reviews on Cancer, 2022 - Elsevier
… with oncogenic signaling pathways and reshape of the tumormetabolism signatures as well
as more activated RAS and … in the shape of inflammatory microenvironment to promote CRC …

Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage

C Ternet, C Kiel - Cell Communication and Signaling, 2021 - Springer
… immune system, inflammation, and metabolism. Recognizing … of the RAS binding effectors
can cause network rewiring and … showed that oncogenic KRAS can activate cancer stem cell …

Metabolic plasticity of melanoma cells and their crosstalk with tumor microenvironment

A Avagliano, G Fiume, A Pelagalli, G Sanità… - Frontiers in …, 2020 - frontiersin.org
… of oncogenic signaling and cancer metabolic reprogramming, … metabolism significantly
contributes to inflammatory tumor … and lumiracoxib restrict energy metabolism by decreasing …

[HTML][HTML] Metabolic reprograming of tumor-associated macrophages

A Puthenveetil, S Dubey - Annals of translational medicine, 2020 - ncbi.nlm.nih.gov
… cell type present in tumor microenvironment (TME) and … PGE2 has pro-oncogenic functions
which help in cancer growth, … equilibrium between the pro and anti-tumoral and inflammatory

The impact of oncogenic RAS on redox balance and implications for cancer development

JKM Lim, G Leprivier - Cell death & disease, 2019 - nature.com
… The capacity of oncogenic KRAS to rewire metabolic … of contributing stimuli from the
microenvironment can also generate … to inflammatory stimuli or other stress conditions, oncogenic

Targeting altered energy metabolism in colorectal cancer: oncogenic reprogramming, the central role of the TCA cycle and therapeutic opportunities

C Neitzel, P Demuth, S Wittmann, J Fahrer - Cancers, 2020 - mdpi.com
… and epigenetic alterations, inflammatory bowel disease, … a response to a changing tumor
microenvironment (TME) and … growth factor (EGF) or by oncogenes like RAS [76,77]. While …