… Role of ion fluxes in the NLRP3 inflammasome activation K+ efflux or Ca2+ influx
induced by NLRP3 activators (eg ATP and nigericin) leads to the mitochondrial damage and …

… , canonical NLRP3 inflammasome activation is a two-step … subsequent signal activates the
NLRP3 inflammasome. Priming … , which activates NF-κB, leading to the upregulation of NLRP3 …

… on how NLRP3 activity is regulated by ion fluxes in the Box 1. Although ionic regulation …
as an immune sensor and effector organ – Orchestrating local and systemic immunity’ (to ZAB …

… This section will review the current knowledge about ion channels’ roles and pore-forming
proteins mediating potassium efflux during NLRP3 inflammasome activation under different …

… as critical innate immune components that orchestrate host immune homeostasis. This …
Indeed, because most stimuli that activate NLRP3 also induce ion fluxes and organelle damage, …

… orchestrate optimal regulation of the NLRP3 inflammasome. … reactive oxygen species (ROS)
generation, ion flux (K + /Cl − efflux, … Ca 2+ flux-triggered NLRP3 inflammasome activation is …

… underlying the activation of the NLRP3 inflammasome. … the activation of the NLRP3
inflammasome by various ions, … various ion channels on the activation of the NLRP3 …

… activation phase are ionic fluxes, mitochondrial dysfunction, and lysosomal damage. Calcium
mobilisation belongs to the signalling events of ionic fluxes … the ionic Ca2+ fluxes and the …

… Specifically, artificial abrogation of Ca 2+ flux from either the extracellular environment or …
oligomerization and pro-caspase-1 processing in NLRP3 inflammasome activation [20]. …

… ion flux disturbances, including Na + and Zn 2+ in orchestrating NLRP3 inflammasome
activation … Although it remains to be answered whether these ions directly bind to NLRP3 and …