… Significant attention has been paid to sleep dysregulation in night eating syndrome (NES),
an eating disorder characterized by a circadian delay in food intake and excessive intake (at …

… and important role in physiological functions ranging from … orexin functions in addiction,
including a particular role for … speed of intoxication with a given substance. Together, recent …

… There is scientific evidence demonstrating that hypocretin-1 and hypocretin-2 are also
involved in the regulation of autonomic nervous system functions. Central hypocretin …

… , orexin/hypocretin (OX) was hypothesized to promote food … , including arousal and drug
seeking, this neuropeptide was … function of OX is to promote foraging behavior, seeking for …

… agent to be approved by the US Food and Drug Administration to treat insomnia. In this …
orexin system with several psychiatric and neurodegenerative diseases. This system constitutes …

… ; the salience or the palatability of food rewards is the main factor driving the behavior [105].
This includes the overconsumption of highly palatable food that is rich in fat and sugar in the …

… CSF concentrations have been studied in medication-overuse-headache and in chronic
migraine, a disorder often accompanied by overuse of pain medication. In both patient groups, …

… System as a Motivational Activation System The brain orexin/hypocretin (referred to here
simply as orexin) system … nervous system (1). Studies over the past 20 years since the orexin …

… , neurons of the hypothalamus, exemplified by orexin/hypocretin neurons, function as “brain
government” systems that convert integrated internal and external information into reactive …

… The present review discusses preclinical studies that demonstrated the involvement of
the Orx system in substance use disorder in general and prescription OUD in particular. …