… Altogether, the results endorse targeting the OX system for the treatment of substance use
… This suggests that SUV could be beneficial in reducing excessive intake that is seen during …

… evidence about the role of DORAs in psychiatric and neurological diseases presenting
insomnia as a comorbidity, and the potential of targeting the orexin system in patients affected by …

… The role of the melanocortin system in drug and alcohol abuse. Int Rev Neurobiol 2017; 136…
Orexin/hypocretin system: Role in food and drug overconsumption. Int Rev Neurobiol 2017; …

… the involvement of the orexinergic system … drug efficacy [53]. It has been suggested that
OXR1-selective antagonists might be potential anti-addiction drugs, but the role of OXR2 in drug …

… of orexins, their involvement in sleep-wake regulation, nociception, and functions relevant to
the … as clinical evidence for the potential involvement of the orexinergic system in headache. …

… a billion disability-adjusted life years, with illicit drugs costing further tens of millions [4]. The
… , eg., overconsumption followed by failed attempts to regulate that overconsumption which …

… These findings suggest that the hyperactivity occurring in the common pathway of the brain
promotes both insomnia as well as the overconsumption of high energy foods which induces …

… after eating, without compensatory mechanisms. The controversial disorder food addiction
(FA) is characterized by overconsumption, cravings, failure to cut down on amounts of food, …

… medication that is outside of the manner and intent for which it was prescribed including
overuse, diversion… controlled medications. Misuse is a necessary but not a sufficient criteria for a …

… -system neuroadaptations The “dark side” model of compulsive eating proposes that
overconsumption of palatable food … reward circuitry, a within-system opponent-process adaptation. …