Artificial Sweeteners in Animal Models of Binge Eating

G Awad, K Befort, MC Olmstead - Animal Models of Eating Disorders, 2021 - Springer
… Binge eating is a common element of many eating disorders and one of the primary factors
… Both binge eating and obesity are driven by overconsumption of highly palatable food that is …

Compulsive eating of binge-like eating prone rats under conditioned fear and exploration of the neural mechanism with c-fos expression

Z Li - 2020 - library-archives.canada.ca
… More interestingly, orexin participates in the regulation of food intake not only via the
metabolic pathway. The Orexin/hypocretin receptor 1 has been found to be necessary for the …

Increase of orexin A in the peripheral blood of adolescents with Internet gaming disorder

MR Choi, H Cho, JW Chun, JH Yoo… - Journal of Behavioral …, 2020 - akjournals.com
Overuse of Internet games also causes depression, anxiety disorders, and cognitive
impairments and is considered a psychiatric disease termed Internet gaming disorder (IGD; Aydm & …

Orexin one receptors within the basolateral amygdala are involved in the modulation of cognitive deficits associated with a migraine-like state in rats

K Askari-Zahabi, M Abbasnejad, R Kooshki… - Neurological …, 2021 - Taylor & Francis
… This study explored the possible role of orexin one receptors (Orx1R) in the basolateral
amygdala (BLA) on the modulation of nitroglycerin (NTG)-induced migraine-like symptoms. In …

Pivotal role of orexin signaling in the posterior paraventricular nucleus of the thalamus during the stress-induced reinstatement of oxycodone-seeking behavior

JM Illenberger, FJ Flores-Ramirez… - Journal of …, 2024 - journals.sagepub.com
drug dependence, the repeated hyperactivation of reward systems by drug use is paralleled
by lower reward system … that the OX system promotes drug seeking that is prompted by drug-…

The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task

J Wiskerke, MH James, G Aston-Jones - Brain research, 2020 - Elsevier
orexin/hypocretin for … role of orexin signaling in executive functions such as response
inhibition changes following exposure to drugs of abuse or following a period of overconsumption

Reward-representing D1-type neurons in the medial shell of the accumbens nucleus regulate palatable food intake

M Durst, K Könczöl, T Balázsa, MD Eyre… - International Journal of …, 2019 - nature.com
… However, according to other data, D2R downregulation cannot be a primary factor in
hyperphagia, but instead is a consequence of overconsumption, increased body mass index and …

Sleep-mediated regulation of reward circuits: implications in substance use disorders

R Guo, DT Vaughan, ALA Rojo… - …, 2023 - nature.com
… with more snacking and over-consumption of high-calorie food [41]. Pregnant women with
poor sleep quality are more likely to have stronger and more frequent food cravings, together …

Embryonic ethanol exposure and optogenetic activation of hypocretin neurons stimulate similar behaviors early in life associated with later alcohol consumption

AD Collier, N Yasmin, O Karatayev, AR Abdulai… - Scientific Reports, 2024 - nature.com
… of early behaviors along with the overconsumption of alcohol during adolescence to be …
-related behaviors, we tested their function in larval zebrafish and found optogenetic activation of …

Orexin neurons mediate temptation-resistant voluntary exercise

AL Tesmer, X Li, E Bracey, C Schmandt… - Nature …, 2024 - nature.com
… , but what drives HPF overconsumption in the first place is … food shortage, the brain evolved
to prioritize feeding over competing demands, thus producing overconsumption when food is …