… important role for HCN channels and I f in long-term heart rate … state, it is associated with
sinus node dysfunction). This work … A screen of microRNAs in the mouse sinus node identified …

… expressed in the SAN, and that expression … mouse model by inserting three point mutations
into the Hcn4 gene, thereby selectively switching off CDR of the channel (HCN4FEA mouse …

… in mouse, which is in line with the much lower heart rate in human compared to … we expressed
HCN4 channels in cardiac myocyte progenitor cells (CMPCs). The use of such expression …

… This suggests that HCN4 channels influence basal excitability of mouse AV node cells, but
… They tested selectivity on HCN channels expressed in HEK cells. Subsequent tests showed …

… A second therapeutic strategy is to restore HCN channel expression in diseased SAN, as …
of HCN channel expression in dogs which can lead to SND [62], [63]. Hence, HCN has been …

… the expression of these regulators with their gene targets and found that sinus node cells …
However, as different isoforms of the HCN channels exhibit varied sensitivity to cAMP [80], …

… for cell adhesion and extracellular matrix organization, respectively. Cluster 4 highly … HCN
channels, K + channels, Ca 2+ channels, transporters and Ca 2+ regulators are all expressed …

… Therefore, we aimed to investigate the function, expression and distribution of HCN4 channels
in the SAN of the type 2 diabetic heart. We hypothesised that type 2 diabetes in ZDF rats …

… and mouse. We conclude that a conserved gene program characterizes the sinoatrial node
… distribution in the SAN and WM, we compared expression profiles of ion channel genes in …

… TRPM7 is a divalent channel kinase abundantly expressed in mouse and human heart. …
We thank the organ procurement organization Lifeline of Ohio and the Division of Cardiac …