A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia
F Serrano Castillo, CA Bertrand, MM Myerburg… - … of Pharmacokinetics and …, 2019 - Springer
… , and osmotically driven transepithelial water dynamics. Model predictions showed CF cultures,
… apical and basolateral water permeabilities, and increase paracellular permeability and …
… apical and basolateral water permeabilities, and increase paracellular permeability and …
[HTML][HTML] What role does CFTR play in development, differentiation, regeneration and cancer?
… With the recent advances in cystic fibrosis transmembrane … ions that generate water influx,
thus creating an osmotic pressure … structures in a 3D epididymal cell culture model [78]. CFTR …
thus creating an osmotic pressure … structures in a 3D epididymal cell culture model [78]. CFTR …
[HTML][HTML] Understanding Bidirectional Water Transport across Bronchial Epithelial Cell Monolayers: A Microfluidic Approach
… cultivated on a porous substrate, spanning a mere 1.12 cm 2 . … acid with low osmotic pressure.
This phenomenon prompts … context of cystic fibrosis, the modulation of water transport is …
This phenomenon prompts … context of cystic fibrosis, the modulation of water transport is …
A simple method to generate human airway epithelial organoids with externally orientated apical membranes
CA Boecking, P Walentek, LT Zlock… - … of Physiology-Lung …, 2022 - journals.physiology.org
… osmotic water permeability was computed from the kinetics of organoid volume, osmotic …
in infected airways of patients with cystic fibrosis and in a cell culture model of S. aureus …
in infected airways of patients with cystic fibrosis and in a cell culture model of S. aureus …
[HTML][HTML] Pathophysiology of lung disease and wound repair in cystic fibrosis
M Conese, S Di Gioia - Pathophysiology, 2021 - mdpi.com
… and reduced the paracellular permeability to small solutes. … a well-differentiated human
airway surface epithelium [172]. … wound repair in primary cultures of CF airway epithelial cells […
airway surface epithelium [172]. … wound repair in primary cultures of CF airway epithelial cells […
Impaired Regulatory Volume Decrease and Characterization of Underlying Volume-Activated Currents in Cystic Fibrosis Human Cholangiocyte Cell Line
B Chen, DM Jefferson, WK Cho - The Journal of Membrane Biology, 2022 - Springer
… cholangiocyte cell line (CF HBDC) are stable, well-differentiated… After the cells were cultured
2–3 days, they are moved to a … For determining the relative permeabilities of various anions, …
2–3 days, they are moved to a … For determining the relative permeabilities of various anions, …
The Physiology of Epithelial ION and Fluid Transport: Beyond CFTR Modulators
L Delpiano, MA Gray - Hodson and Geddes' Cystic Fibrosis, 2023 - taylorfrancis.com
… However, both the ion selectivity and water permeability of … osmotically driven water transport
to follow in the same direc… , and in vitro studies on CF airway cultures, suggested that they …
to follow in the same direc… , and in vitro studies on CF airway cultures, suggested that they …
Organoids as a model for intestinal ion transport physiology
HR de Jonge, MJC Bijvelds, AM Strubberg… - Ion Transport Across …, 2020 - Springer
… organoids cultured from rectal biopsies of cystic fibrosis … and introduced the culture of
well-differentiated, intestinal epithelial … in studies of epithelial permeability, mucus production and …
well-differentiated, intestinal epithelial … in studies of epithelial permeability, mucus production and …
[HTML][HTML] Modulator combination improves in vitro the microrheological properties of the airway surface liquid of cystic fibrosis airway epithelia
A Ludovico, O Moran, D Baroni - International Journal of Molecular …, 2022 - mdpi.com
… of water is passive, being generally driven by the osmotic … to the increase of bicarbonate
permeability of the corrector-rescued … Culture media and supplements used in this article were …
permeability of the corrector-rescued … Culture media and supplements used in this article were …
[HTML][HTML] Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia
C van Heusden, B Button… - … of Physiology-Lung …, 2020 - journals.physiology.org
… cultures from four non-cystic fibrosis (CF) (control, CTL) and four CF donors. Values were
log transformed to achieve normality, … (hydration) to mucus osmotic pressure and transport in …
log transformed to achieve normality, … (hydration) to mucus osmotic pressure and transport in …