[HTML][HTML] Oxidative Stress Causes Vacuolar Fragmentation in the Human Fungal Pathogen Cryptococcus neoformans
Vacuoles are dynamic cellular organelles, and their morphology is altered by various stimuli
or stresses. Vacuoles play an important role in the physiology and virulence of many fungal
pathogens. For example, a Cryptococcus neoformans mutant deficient in vacuolar functions
showed significantly reduced expression of virulence factors such as capsule and melanin
synthesis and was avirulent in a mouse model of cryptococcosis. In the current study, we
found significantly increased vacuolar fragmentation in the C. neoformans mutants lacking …
or stresses. Vacuoles play an important role in the physiology and virulence of many fungal
pathogens. For example, a Cryptococcus neoformans mutant deficient in vacuolar functions
showed significantly reduced expression of virulence factors such as capsule and melanin
synthesis and was avirulent in a mouse model of cryptococcosis. In the current study, we
found significantly increased vacuolar fragmentation in the C. neoformans mutants lacking …
[PDF][PDF] Oxidative Stress Causes Vacuolar Fragmentation in the Human Fungal Pathogen Cryptococcus neoformans. J. Fungi 2021, 7, 523
Vacuoles are dynamic cellular organelles, and their morphology is altered by various stimuli
or stresses. Vacuoles play an important role in the physiology and virulence of many fungal
pathogens. For example, a Cryptococcus neoformans mutant deficient in vacuolar functions
showed significantly reduced expression of virulence factors such as capsule and melanin
synthesis and was avirulent in a mouse model of cryptococcosis. In the current study, we
found significantly increased vacuolar fragmentation in the C. neoformans mutants lacking …
or stresses. Vacuoles play an important role in the physiology and virulence of many fungal
pathogens. For example, a Cryptococcus neoformans mutant deficient in vacuolar functions
showed significantly reduced expression of virulence factors such as capsule and melanin
synthesis and was avirulent in a mouse model of cryptococcosis. In the current study, we
found significantly increased vacuolar fragmentation in the C. neoformans mutants lacking …
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