Oxytocin treatment for alcoholism: Potential neurocircuitry targets

J Peris, MR Steck, EG Krause - Neuropharmacology, 2020 - Elsevier
… tegmental area (VTA) to nucleus accumbens (NAc) to signal … potential of OT treatment for
alcohol use disorder (AUD) by … evidence indicating OT inhibits motivation for ethanol reward, …

[HTML][HTML] Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

BJ Tunstall, D Kirson, LJ Zallar, SA McConnell… - PLoS …, 2019 - journals.plos.org
nucleus of the amygdala (CeA; a key brain region in the network of dysregulations induced
by alcohol dependence) indicated that oxytocin … effects of oxytocin, including inhibition of …

Alcohol and oxytocin: scrutinizing the relationship

AE Ryabinin, HD Fulenwider - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Alcohol inhibits oxytocin release from hypophyseal terminals in males and females. …
accompanied by increased OXTR mRNA levels in several cortical areas, nucleus accumbens (NAC), …

Environmental enrichment enhances ethanol preference over social reward in male swiss mice: Involvement of oxytocin-dopamine interactions

M Rae, I Gomes, LEW Spelta, A Bailey… - …, 2024 - Elsevier
levels in the nucleus accumbens (A) Levels of D 1 receptors in the NAc of CT and EE groups
(n = 7–8/group) (B) Levels … to amphetamine inhibits the formation of mating-induced partner …

Oxytocin reverses ethanol consumption and neuroinflammation induced by social defeat in male mice

MD Reguilón, C Ferrer-Pérez, J Miñarro… - Hormones and …, 2021 - Elsevier
… There are no studies evaluating the potential effect of OXT on the increased consumption
of EtOH induced by social defeat. However, we know that mice treated with OXT prior to each …

The role of oxytocin in alcohol and drug abuse

CE King, A Gano, HC Becker - Brain research, 2020 - Elsevier
… reduced alcohol-induced CPP and alcohol consumption in … Moreover, alcohol-induced
elevation of dopamine release … ), and this inhibition was associated with a reduction in alcohol

Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors

CE King, WC Griffin, MF Lopez… - …, 2021 - nature.com
… containing neurons in the paraventricular nucleus of the hypothalamus (PVN) alters alcohol
… mechanism whereby exogenous OT stimulates hypothalamic release of endogenous OT [24,…

Systemic oxytocin administration alters mesolimbic dopamine release in mice

MK Estes, TG Freels, WT Prater, DB Lester - Neuroscience, 2019 - Elsevier
… transmission in areas associated with anxiety and addiction, the amygdala and the nucleus
… NAc but not amygdala dopaminergic response to a DAT inhibitor. These regional variations …

[HTML][HTML] Oxytocin and addiction: potential glutamatergic mechanisms

M Sundar, D Patel, Z Young, KC Leong - International journal of …, 2021 - mdpi.com
… in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) … show that alcohol can
inhibit presynaptic Glu release and … found Glu levels to increase after alcohol administration, …

The potential role of oxytocin in addiction: What is the target process?

F Sanna, MA De Luca - Current Opinion in Pharmacology, 2021 - Elsevier
… bed nucleus of the stria terminalis as a key structure where … of Ethanol-induced dopamine
release and reduced EtOH self… for the ability of oxytocin to inhibit ethanol-induced negative …