[HTML][HTML] Overexpression of CCDC69 activates p14ARF/MDM2/p53 pathway and confers cisplatin sensitivity

L Cui, F Zhou, C Chen, CC Wang - Journal of Ovarian Research, 2019 - Springer
… role in enhancing cells to cisplatin-induced cell death. … of p21 expression in an entirely
p53-independent fashion, as the … of p14 ARF in sensitizing p53 mutated osteosarcoma cells to …

[HTML][HTML] Platinum complexes in colorectal cancer and other solid tumors

B Köberle, S Schoch - Cancers, 2021 - mdpi.com
… will allow cancer cells to evade cisplatin-induced cell death [14… of cell death via p53 signaling,
a p53-independent apoptotic … -methylating agent decitabine sensitized human colon tumor …

[HTML][HTML] Genetic alterations in the ink4a/arf locus: effects on melanoma development and progression

Z Ming, SY Lim, H Rizos - Biomolecules, 2020 - mdpi.com
… that expression of p14 ARF and/or p16 INK4a may sensitize cancer cells to imatinib treatment
[… observed in osteosarcoma cell lines in response to cisplatin-induced apoptosis, however, …

[HTML][HTML] c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

YC Feng, XY Liu, L Teng, Q Ji, Y Wu, JM Li… - Nature …, 2020 - nature.com
… a negative feedback manner to maintain cellular homeostasis … of ARF tumor suppressor (p14
ARF in human and p19 ARF in … Human osteosarcoma U2OS cells were cultured in MacCoy’…

[HTML][HTML] Triangular relationship between p53, autophagy, and chemotherapy resistance

J Xu, NH Patel, DA Gewirtz - International Journal of Molecular Sciences, 2020 - mdpi.com
… with autophagy through the p14ARF (p19ARF in mouse, and … resensitize H460/cis cells to
cisplatin-induced cell death [84]. … -induced cell death also in a p53-independent manner [115]. …

[HTML][HTML] A potential role for HUWE1 in modulating cisplatin sensitivity

S Wenmaekers, BJ Viergever, G Kumar, O Kranenburg… - Cells, 2021 - mdpi.com
… Interestingly, the response to dexamethasone, a p53-independent inducer of apoptosis, … ,
thereby sensitizing to platins, has yet to be researched. However, broadly targeting of p14ARF

[HTML][HTML] Mechanisms of TP53 pathway inactivation in embryonic and somatic cells—relevance for understanding (germ cell) tumorigenesis

DM Timmerman, TL Remmers, S Hillenius… - International Journal of …, 2021 - mdpi.com
… We discuss that P14 ARF (ARF) functions as a negative … and NOXA) after cisplatin-induced
DNA damage [106]. … and was most likely regulated in a P53-independent manner [39]. It was …

[HTML][HTML] Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives

MM Faheem, ND Seligson, SM Ahmad, RU Rasool… - Cell death …, 2020 - nature.com
… Additionally, p14 ARF and its murine counterpart, p19 ARF , … and sensitize cancer cells
to activation of senescence 40 . … senescence in a p53-independent manner. Additionally, …

[HTML][HTML] Role of long non-coding RNA polymorphisms in cancer chemotherapeutic response

Z Zhang, M Gu, Z Gu, YR Lou - Journal of personalized medicine, 2021 - mdpi.com
… rate of cisplatin-induced apoptosis, and the result is that lung cancer cells enhance
cisplatin … According to previous studies, ANRIL regulates epigenetic silencing of p14ARF (or …

The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy

A Basu - Pharmacology & therapeutics, 2022 - Elsevier
… -dependent manner (Nelyudova, Aksenov, Pospelov, & Pospelova, 2007). The exogenous
short chain C2 ceramide also sensitized non-small cell lung carcinoma (NSCLC) cells to …