… Although originally isolated in the central nervous system … PACAP is a well-established
modulator of innate and acquired … anti- and pro-inflammatory roles of PACAP depending on the …

… , despite trans-signalling playing a dominant role in modulating IL-6 driven activities of two
main … of peripheral inflammatory cells may be required for the induction of PACAP expression. …

… and neurons in the central nervous system (CNS). Chronic inflammation leads to …
immunoprotective actions of PACAP in EAE are in part mediated through modulation of the …

… injections of the PACAP peptide in specific CNS regions increase BDNF production [191,192]. …
PACAP and VIP as “broad microglia modulators”, able to stimulate an anti-inflammatory …

… anti-inflammatory and neuroprotective properties, modulating the … However, the role of
chemokines and cytokines modulated … resident cells of the central nervous system, originate in the …

… and ameliorate the peripheral nerve inflammatory response … PACAP is neuroprotection in
both the central nervous system (… Moreover, these cells modulate pain sensitivity in peripheral …

… Here, we reveal that PACAP administration reduced the inflammatory foci and the number of
… that PACAP effects are likely due to modulation of immune cell recruitment to the CNS and …

… PACAP inhibit the release of pro-inflammatory … PACAP have important paracrine effects in
the distal nerve stump to promote remyelination and resolve the peripheral nerve inflammatory …

… The specific PAC1 receptor binds PACAP with much … to PACAP and VIP. It has a widespread
distribution throughout the entire body both in the central nervous system and peripheral …

… PACAP/VIP effects in the CNS. In particular, … inflammatory microglia and increased survival
of substantia nigra dopaminergic neurons in rat models of PD. Thus, activation of peripheral …