… as being resistant to solubilization in detergents and dependent on cholesterol. …
Phospholipase C Enzymes There are several PI-specific proteins that recognize and bind to …

… While the possibility that cholesterol binds directly to proteins was proposed in the mid-… 3.1
Receptor-Stimulated Phospholipases C Activation of phospholipases C (PLCs) cleaves PIP2 …

… For instance, PLC has been shown to accumulate within lipid rafts that consist of cholesterol…
of PLCε is sufficient to prevent Ras binding of the enzyme in a GTP-dependent manner [7]. …

… Mammalian phospholipase C (PLCs) are effector proteins that are activated downstream of
… Its canonical role in the cell is in binding phosphatidylinositol (PI) species with high affinity …

… PMP2 binds more strongly to PI(4,5)P2 and sequesters PI(4,5)P2 … is that the sequestration
of PI(4,5)P2 by the PMP2(I43N) … , we found that PMP2 can bind both PI(4,5) P2 and PI(3,5)P2. …

… Phospholipase C (PLC) catalyses the cleavage of the glycerophosphate bond (more precisely,
the cleavage of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2 … (4,5)P 2 binding …

… expression of the NOTCH ligand delta-like 4 (DLL4) in tip cells, … , phospholipase C (PLC),
which hydrolyzes PI(4,5)P 2 to … -binding protein-related protein 2; Osbpl2), a cholesterol-PI(4,…

… The phosphoinositide, phosphatidylinositol 4,5-bisphosphate (… of its role as a substrate for
phospholipase C (PLC). Signaling by … Although PIP 2 can bind to the C terminus of the Kir6.1 …

… core signaling modules, including phospholipase C (PLC) enzymes (1). PLC enzymes …
cholesterol. On the basis of these results, we propose a model of PLCγ1 core membrane binding, …

… PI(4,5)P 2 intracellular distribution in THP-1 macrophages, since this probe is known to
selectively bind PI(4,5)P 2 lipids and is widely used for deciphering PI(4,… cholesterol on PI(4,5)P 2 …