… Phospholipase C-delta (PLC-δ) interacts specifically with PI(… of WIPI 1,2,3 and 4 were
shown to bind to PI(3,5)P2 with high … (PC), sphingomyelin and cholesterol is determined to be …

… with phospholipase C enzymes 389 4. Thermostable phospholipases 391 5. Use of …
Phosphatidylinositols (PI(4,5)P2 and PI(3,4,5) P3) bind with great affinity to the PH domain of PLC …

… (A1 and A2), phospholipases C, and phospholipases D are … the synthesis of FA, cholesterol,
and TAG while promoting the … Importantly, gelsolin is bound to PtdIns(4,5)P2 in its resting …

… receptor-stimulated activation of phospholipase C (PLC), that is, … From a global, somewhat
superficial perspective, PI 4-… membrane lipids, such as cholesterol and sphingomyelin, which …

… to bind different lipids including cholesterol (1), oxysterols (2), and phospholipids (Figure 1)
1,… ORP4L was found to interact with GPCR components, phospholipase C β3 (PLCβ3), CD3ε, …

… of phospholipase C δ1 (PLCδ1), which cleaves PtdIns(4,5)P 2 … 1 binding to PtdIns(4,5)P 2
[77]. It produces this effect by … Moreover, the high cholesterol level found in synaptic vesicles …

… -binding protein Rab10. We demonstrate that TREs are enriched in both phosphatidic acid
(PA) and phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), … We next used phospholipase D …

… (POPE), palmitoylsphingomyelin, cholesterol, and PI(4,5)P 2 at relevant ratios to model the
… PM by binding PI(4,5)P 2 . PLCδ-PH (pleckstrin homology domain of phospholipase C delta) …

… kinases to increase intracellular calcium through another phospholipase C family, PLCγ. …
PI(4,5)P 2 . This hydrolysis releases Ins(1,4,5)P 3 into the cytosol, which then binds to Ins(1,4,5…

… were compared to control (delta filipin fluorescence intensity). … phospholipase C δ1 (PLC-δ1),
a PI(4,5)P 2 sensor that displays a high selectivity and binding efficiency towards PI(4,5)P 2 …