Roles of PI3K/AKT/GSK3 pathway involved in psychiatric illnesses

S Matsuda, Y Ikeda, M Murakami, Y Nakagawa, A Tsuji… - Diseases, 2019 - mdpi.com
Psychiatric illnesses may be qualified to the cellular impairments of the function for survival
or death in neurons, which may consequently appear as abnormalities in the neuroplasticity. …

Motor learning deficits and striatal GSK-3 hyperactivity in Akt3 knockout mice.

B Ouimet, É Pépin, Y Bergeron, L Chagniel… - Behavioral …, 2019 - psycnet.apa.org
… We propose that motor learning impairments observed in the Akt3 KO mice are caused by a
… GSK-3 activity in memory processes during the learning of new complex motor tasks in mice. …

[图书][B] Abnormalities in the AKT-mTOR Signaling Pathway in the Dorsolateral Prefrontal Cortex in Schizophrenia

R Chadha - 2020 - search.proquest.com
… and Law, AJ (2017) ‘PKBγ/AKT3 loss-of-function causes learning and memory deficits
and deregulation of AKT/mTORC2 signaling: Relevance …

Downregulated AKT-mTOR signaling pathway proteins in dorsolateral prefrontal cortex in Schizophrenia

R Chadha, JH Meador-Woodruff - Neuropsychopharmacology, 2020 - nature.com
… to learning and memory deficits associated with SZ. In addition, the AKT-mTOR signaling
pathway is influenced by signals from neurotransmitter receptors, growth factors, and cellular …

PI3K-AKT/mTOR Signaling in Psychiatric Disorders: A Valuable Target to Stimulate or Suppress?

Y Chen, W Guan, ML Wang… - International Journal of …, 2024 - academic.oup.com
… Howell KR, Floyd K, Law AJ (2017) PKBγ/AKT3 loss-of-function causes learning and memory
deficits and deregulation of AKT/mTORC2 signaling: relevance for schizophrenia. PLoS …

Electroacupuncture of Baihui and Shenting ameliorates cognitive deficits via Pten/Akt pathway in a rat cerebral ischemia injury model

K Su, W Hao, Z Lv, M Wu, J Li, Y Hu, Z Zhang… - Frontiers in …, 2022 - frontiersin.org
… To exclude rats with congenital dementia from our project, the spatial learning and memory
… Additionally, the effect of EA treatment on the spatial learning and memory abilities of MCAO/…

Protein kinase B/Akt1 phosphorylates dysbindin-1a at serine 10 to regulate neuronal development

E Fei, P Chen, Q Zhang, Y Zhong, T Zhou - Neuroscience, 2022 - Elsevier
… -1A rescued the dendrite and spine deficits in dysbindin-1A … Therefore, dysbindin-1
loss-of-function contributes to the … /Akt1, PKBβ/Akt2 and PKBγ/Akt3) encoded by separate genes. …

TDP-43 KNOCKDOWN IN MOUSE MODEL OF ALS LEADS TO DSRNA DEPOSITION, ASTROGLIOSIS, IMMUNE ACTIVATION, AND NEURODEGENERATION IN …

R Milstead, C Link, Z Xu, C Hoeffer - MOLECULAR SIGNALING AND … - search.proquest.com
… recent hypothesis suggests that TDP-43 dysfunction may lead to deficits in … This RNAi leads
to a partial loss of function and age-related motor dysfunction, similar to human ALS (Yang et …

Phosphoinositides: regulators of nervous system function in health and disease

P Raghu, A Joseph, H Krishnan, P Singh… - Frontiers in molecular …, 2019 - frontiersin.org
… In contrast, null mutations in FIG4 resulting in complete loss of function is the cause of
Yunis-Varon syndrome, which is characterized by severe neurological impairment affecting central …

[PDF][PDF] Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: Multi-level study of postmortem brain

泉竜太 - 2022 - ir.fmu.ac.jp
… disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation…
PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2