… required for TCR-induced T cell activation, … (NF-κB) reporter gene in transfected Jurkat
T cells (36). To more rigorously explore the importance of pTyr binding for PKCθ’s TCR-induced …

… 1 mediates TCR-induced T cell migration and activation by … of PDK1 in T cells abrogates
activation of NF-κB and PKCθ … , immature/mature T cells, and natural killer cells 165,168,169 …

… required for activation, proliferation, differentiation and survival of immune … activated leads
to the recruitment and activation of NF-κB, AP-1 and NF-AT (nuclear factor of activated T cells) …

… essential for the generation of transcriptionally active P-… PKC-θ is considered to be the
predominantly functional PKC isoform in T cells and it critically mediates both TCR-induced NF-κB …

… expressed in T cells and involved in TCR-induced proliferation… for NF-κB activation, we
generated PKCθ knockout cells on … of PKC-θ to membrane rafts is required for T cell activation. …

… natural killer T cells, thymocytes, and thymic T regulatory cells. We … NF-κB also regulates
TCR-induced expression of lymphotoxin (… that PKC-θ- mediated TCR signals are required for the …

… kappa B (NF-κB), AP-1, and nuclear factor of activated T-cells (… for the effective, TCR-induced
activation of AP-1. We show … resting mature and immature T cells, but is critical for the …

… PKC is essential for full activation of the Ras/ERK and NF-κB … to activation of the serine-threonine
kinase PKC-θ. PKC … or restrict potential for TCR-induced cellular activation and balance …

… , as an essential prerequisite for full NF-κB activation [9]. … to the normal T cell development
observed, TCR-induced … and NF-κB transcription factors in activated T219A CD4 + T cells. …

… factor kappa B (NF-κB), and nuclear factor of activated T cells (… are several Th17 differentiation
mechanisms that require … PKCθ acts in various capacities in mature CD4 T cells, from …