Propofol ameliorates neuropathic pain and neuroinflammation through PPAR γ up-regulation to block Wnt/β-catenin pathway

P Jiang, Q Jiang, Y Yan, Z Hou, D Luo - Neurological Research, 2021 - Taylor & Francis
rat models were established after anesthesia and ligation on sciatic nerves. To evaluate the
pain sensitivity of CCI rats… , in our study, we found that propofol decreased GFAP, TNF-α, IL-…

PPAR γ prevents neuropathic pain by down-regulating CX3CR1 and attenuating M1 activation of microglia in the spinal cord of rats using a sciatic chronic constriction …

X Li, Q Guo, Z Ye, E Wang, W Zou, Z Sun… - Frontiers in …, 2021 - frontiersin.org
… PWLs in CCI rats were significantly decreased on postoperative days … This study found that
CCI rats had a higher level of M1 … the development of NP by inhibiting M1 microglia activation, …

[HTML][HTML] PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway

YQ Zhou, DQ Liu, SP Chen, N Chen, J Sun… - Biomedicine & …, 2020 - Elsevier
… To determine whether early treatment with PPARγ agonist could suppress the development
… study, we found that the spinal expression of PPARγ was significantly reduced in PINP rats. …

Nuclear PPARActivation Modulates Inflammation and Oxidative Stress in Attenuating Chemotherapy-Induced Neuropathic Pain in Vivo

H Pasupulati, SSV Padi… - Journal of …, 2021 - open.journal4submit.com
… attenuated established paclitaxel-induced neuropathic pain … the development of peripheral
neuropathic pain in Wistar rats… a PPARγ agonist, reduces cisplatin-evoked neuropathic pain

Targeting Peroxisome Proliferator-Activated Receptor-α (PPAR-α) to reduce paclitaxel-induced peripheral neuropathy

M Caillaud, NH Patel, A White, M Wood… - Brain, behavior, and …, 2021 - Elsevier
… sensory neuropathy, often accompanied by neuropathic pain … the development of PIPN in
C57BL/6J male and female mice. … In addition, this lipid-lowering drugs have an established

PPARs and pain

BN Okine, JC Gaspar, DP Finn - British journal of pharmacology, 2019 - Wiley Online Library
… both inflammatory and neuropathic pain as discussed later. … in PPARγ knockout mice. De
Guglielmo et al. (2014) … of PPARα or PPARγ activation at multiple sites within the pain pathway, …

Building and testing PPARγ therapeutic ELB00824 with an improved therapeutic window for neuropathic pain

KN Westlund, M Zhang - Molecules, 2020 - mdpi.com
neuropathic pain in mouse and rat is only 3–10 mg/kg, equivalent to 15–49 mg/kg in human.
This is lower than … We found that the RCR was compromised in the cortex of mice with the …

… prevents paclitaxel‐induced neuropathic nociception through activation of PPARγ signalling pathway and inhibition of neuroinflammation in rat dorsal root ganglion

S Zhong, Z Zhou, X Lin, F Liu, C Liu… - European Journal of …, 2021 - Wiley Online Library
… in the peroxisome growth factor activated receptor (PPAR) … Considering the lower glucose
observed in KD rats, we also … , it was found that KD alleviated the severity of neuropathic

Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPARγ to Inhibit the NF‐κB/NLRP3 Inflammatory Axis in …

J Fu, B Zhao, C Ni, H Ni, L Xu, Q He, M Xu… - PPAR …, 2021 - Wiley Online Library
pain [19], neuropathic pain [20], and other chronic pain [21]. … We found that intrathecal
injection of rosiglitazone reduced … Sprague-Dawley rats and cancerous ascites developed after 6…

Effects of Dual Peroxisome Proliferator‐Activated Receptors α and γ Activation in Two Rat Models of Neuropathic Pain

M Alsalem, M Haddad, SA Aldossary… - PPAR …, 2019 - Wiley Online Library
… for their ability to reduce peripheral neuropathic pain [11, 12]. … and PPARγ agonists to alleviate
peripheral neuropathic pain… the development of chemotherapy-induced neuropathic pain, …