… also shown a heterogeneous group of cells in the blood with different staining and KRAS …
the DNA of enriched cells for tumor-specific mutations in PDAC—typically KRAS. This also …

… , heterogeneity of tumor cells, and contamination by stromal … KRAS mutation was found
compared to their primary tumor [130]. … of the cancer where tumor cells acquired mutations in their …

… intratumoral heterogeneity of point mutations in KRAS … of HER2 status of matched primary
tumors in this study, … reliably detect point mutations in KRAS from pancreatic CTCs [53…

… First, detection of mutant KRAS ctDNA prior to surgery or in … of epithelial and mesenchymal
circulating tumor cells during … functional driver gene heterogeneity among metastases (52). …

… information about the genetics of pancreatic cancer CTCs. DNA analysis by … shown
heterogeneous CTC populations harboring different DNA mutations such as in Case #6 with KRAS …

… , a prior study evaluating heterogeneity in ctDNA genomic … whose tissues were biopsied
from primary tumors (72% versus … in pancreatic cancer [52, 53] or that the presence of KRAS …

… The heterogeneity of the mutational status is clearly present … of mutations in CTCs and
matched primary tumors. When … KRAS mutation analysis of single circulating tumor cells from …

… Pancreatic cancer is detected late in the disease process and … In essence, there is much
heterogeneity in the methods used … cfDNA and 772 days in patients without the KRAS mutant …

… PDAC such as related cancer-driving mutations. Elucidating the … means to define tumor cell
heterogeneity and mitigate the … between vimentin expression in primary tumors and disease …

… Hepatocellular carcinoma (HCC) and pancreatic cancer (PC) belong … Both highly
heterogeneous visceral carcinomas exhibit … to the circulation by tumor cells of different cancer …