… alterations (CNAs) has broad applications in cancer research. … One pair of tumor-normal
matched samples is picked from … using CLT that we call Deviation Binary Segmentation (DBS) …

… The data set used in this thesis has a matched normal sample available for all tumor …
Parent-specific copy number in paired tumor–normal studies using circular binary segmentation…

… Oncogene activation and tumor suppressor gene inactivation … the average insert size between
the sequenced read-pairs … LNH-03B LYSA trials with available frozen tumor samples and …

… A patient-matched normal sample or a reference pool of non-… binary segmentation40.
Segments are annotated with known … or gene, as previously reported in other studies47. The …

… Previous research on genetic variations in prostate cancer … includes the parent-specific
circular binary segmentation (… copy number, to define segments in the dataset (23). For each …

… cell lines, the identity of which was matched between the CCLE and the GDSC datasets [40,…
using the circular binary segmentation algorithm [40, 41]. These continuous copy number …

… arm 17p across all tumor types, copy number losses at this … An important challenge in
genome-wide cancer studies is to … Parent-Specific Circular Binary Segmentation (Paired PSCBS…

… We describe a new strategy for studying tumor heterogeneity … from the same tumor sections,
we reveal clone-specific … qPCR testing revealed approximately disomic copy numbers …

… Jude Children’s Research Hospital were considered in our … v.0.9.10.dev0 utilizing a circular
binary segmentation method [34,35,36]. … Table 1 Targets of subchromosomal copy number …

… DNA I will analyze these structures in a subset of tumors in … )s, that establish parent-specific
expression. ICRs exhibit patterns … SCNAs include deviations in chromosomal copy number, …