[HTML][HTML] Pathophysiological perspective of osteoarthritis

MHM Yunus, A Nordin, H Kamal - Medicina, 2020 - mdpi.com
Osteoarthritis (OA) is the most common cause of chronic joint pain among the geriatric … With
the advancement of molecular biology, the paradigm of OA pathophysiology has shifted to it …

[HTML][HTML] Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee

S Jang, K Lee, JH Ju - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain, …

[HTML][HTML] Osteoarthritis: New insight on its pathophysiology

S Coaccioli, P Sarzi-Puttini, P Zis, G Rinonapoli… - Journal of Clinical …, 2022 - mdpi.com
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements in
recent years. It has been observed that cartilage degeneration is preceded by subchondral …

[HTML][HTML] Extracellular vesicles in the synovial joint: is there a role in the pathophysiology of osteoarthritis?

A Esa, KD Connolly, R Williams… - Malaysian orthopaedic …, 2019 - ncbi.nlm.nih.gov
Osteoarthritis was generally considered to be a ‘wear and tear’ disease, predominantly …
shift of our view of the pathophysiology of OA. Osteoarthritis is now recognised as a complex …

Ageing and osteoarthritis

PK Sacitharan - Biochemistry and cell biology of ageing: part II clinical …, 2019 - Springer
… increased the prevalence of osteoarthritis which is now the … osteoarthritis which causes
pain and may lead to a crippling loss of function in patients. The pathophysiology of osteoarthritis

[HTML][HTML] Macrophages in osteoarthritis: pathophysiology and therapeutics

Y Chen, W Jiang, H Yong, M He, Y Yang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain. …

Osteoarthritis: Pathophysiology and current treatment modalities

KR Pagar, SV Khandbahale… - Asian Journal of …, 2019 - indianjournals.com
Osteoarthritis (OA) is accepted as a major public health problem. It is one of the major causes
of impaired function that reduces quality of life (QOL) worldwide. OA is a very common …

Fundamentals of osteoarthritis: Inflammatory mediators in osteoarthritis

A De Roover, A Escribano-Núñez… - Osteoarthritis and …, 2023 - Elsevier
… As more has become known of the pathophysiology of osteoarthritis (OA), evidence that
inflammation plays a critical role in its development and progression has accumulated. Here, we …

[PDF][PDF] Osteoarthritis pathophysiology: therapeutic target discovery may require a multifaceted approach

TL Vincent, T Alliston, M Kapoor, RF Loeser… - Clinics in geriatric …, 2022 - Elsevier
Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic ‘∼ …

[HTML][HTML] The involvement of neutrophils in the pathophysiology and treatment of osteoarthritis

S Chaney, R Vergara, Z Qiryaqoz, K Suggs, A Akkouch - Biomedicines, 2022 - mdpi.com
… radiographic knee osteoarthritis and 9.5% for symptomatic knee osteoarthritis [12,13]. In
this study, the prevalence of both radiographic and symptomatic knee osteoarthritis increased …