Development of Bioinformatics Software Tools for Network-and Pathway-Based Exploration of miRNA Target Interactions

S Haunsberger - 2022 - repository.rcsi.com
… rather to regulate the lin-14 mRNA. Later, in 2000, two independent laboratories found that
… It was originally believed that this novel type of gene expression regulation was unique to C. …

A multi-omics interpretable machine learning model reveals modes of action of small molecules

NL Patel-Murray, M Adam, N Huynh, BT Wassie… - Scientific reports, 2020 - nature.com
… effects in models of Huntington’s Disease, we foundgene expression profiles of human
lymphoma cells treated with anti-cancer drugs were compared using the gene regulatory network

Data mining for mutation-specific targets in acute myeloid leukemia

B Benard, AJ Gentles, T Köhnke, R Majeti, D Thomas - Leukemia, 2019 - nature.com
… somatic mutations involving genes that regulate DNA methylation… different pathway-based
approaches. In the parallel pathway … methodology to discover “hidden” relationships in clinical …

Integrated analysis of endoplasmic reticulum stress regulators' expression identifies distinct subtypes of autism spectrum disorder

Y Li, S Gao, Y Meng - Frontiers in Psychiatry, 2023 - frontiersin.org
… We found that ER stress regulators can well distinguish … variables; Each neuron in the hidden
and output layers is linked to … Individuals with UBA5 variants can develop severe irritability, …

MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1

Q Liu, A Hou, Y Zhang, Y Guo, J Li, Y Yao, K Niu, H Li… - BMC genomics, 2019 - Springer
… The mice were trained to find the hidden platform and climb … up-regulation miRNAs and 103
significantly down-regulationpathway-based enrichment analysis of these 169 genes and …

Immune-Omics Networks of CD27, PD1, and PDL1 in Non-Small Cell Lung Cancer

Q Ye, S Singh, PR Qian, NL Guo - Cancers, 2021 - mdpi.com
… The significant genetic associations (p < 0.05, z-tests) found … Mitoxantrone is mainly used
to treat acute myeloid leukemia, … a CNV-mediated transcriptional regulatory network of CD27, …

Recognition of plausible therapeutic agents to combat COVID-19: An omics data based combined approach

MU Hossain, A Bhattacharjee, MTH Emon… - Gene, 2021 - Elsevier
… , a Gene Expression Omnibus (GEO) dataset of Severe Acute … In this analysis, 13
immunoregulatory genes were found that … to find out genes that are connected in cytokine …

From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models

M Mew, KA Caldwell, GA Caldwell - Human Molecular Genetics, 2022 - academic.oup.com
… mutations produced less severe phenotypes, underscoring … models to provide direct functional
annotation of SNPs found … is mediated by the mitophagy regulatory gene product, PINK1. …

Identification of common genes and pathways between type 2 diabetes and COVID-19

Y Wang, K Li, S Mo, P Yao, J Zeng, S Lu, S Qin - Frontiers in Genetics, 2024 - frontiersin.org
… a high incidence and risk of severe illness due to coronavirus … and free nodes hidden,
resulting in a PPI network with 219 … regulatory network, which consisted of five common feature …

Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality

S Benfatto, Ö Serçin, FR Dejure, A Abdollahi… - Molecular Cancer, 2021 - Springer
… of the model, and (ii) all-relevant methods, that find all the … (Functional Analysis through
Hidden Markov Models) predictions [22], … and are involved in cell cycle regulation. In the case of …