How I treat pediatric acute myeloid leukemia

JE Rubnitz, GJL Kaspers - Blood, The Journal of the American …, 2021 - ashpublications.org
… Treatment outcomes for pediatric patients with acute myeloid leukemia (AML) have continued
to lag behind outcomes reported for children with acute lymphoblastic leukemia (ALL), in …

Pediatric acute myeloid leukemia—past, present, and future

D Reinhardt, E Antoniou, K Waack - Journal of clinical medicine, 2022 - mdpi.com
… This review reports about the main steps of development in pediatric acute myeloid
leukemia (AML) concerning diagnostics, treatment, risk groups, and outcomes. Finally, a …

Cytogenetics of pediatric acute myeloid leukemia: a review of the current knowledge

J Quessada, W Cuccuini, P Saultier, M Loosveld… - Genes, 2021 - mdpi.com
Pediatric acute myeloid leukemia is a rare and … current WHO classification of acute myeloid
leukemia, where there … an updated review of cytogenetics in pediatric AML, describing well-…

Pediatric relapsed acute myeloid leukemia: a systematic review

AE Hoffman, LJ Schoonmade… - Expert review of …, 2021 - Taylor & Francis
Introduction: Pediatric relapsed acute myeloid leukemia (AML) remains lethal in the majority
of cases, despite intensive therapy. Randomized trials are largely lacking, and the main …

Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia

NA McNeer, J Philip, H Geiger, RE Ries, VP Lavallee… - Leukemia, 2019 - nature.com
Acute myeloid leukemias (AML) are characterized by mutations of tumor suppressor and
oncogenes, involving distinct genes in adults and children. While certain mutations have been …

Pediatric acute myeloid leukemia (AML): from genes to models toward targeted therapeutic intervention

T Mercher, J Schwaller - Frontiers in pediatrics, 2019 - frontiersin.org
… of the genetic lesions driving pediatric acute myeloid leukemia (AML), … or exclusively occur
in pediatric patients and molecular … faced to faithfully model pediatric acute leukemia in mice. …

New and emerging targeted therapies for pediatric acute myeloid leukemia (AML)

J Chen, CL Glasser - Children, 2020 - mdpi.com
The relapse rate for children with acute myeloid leukemia (AML) remains high despite
advancements in risk classification, multi-agent chemotherapy intensification, stem cell …

Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia

N Shiba, K Yoshida, Y Hara, G Yamato… - Blood …, 2019 - ashpublications.org
… Recent advances in the genetic understanding of acute myeloid leukemia (AML) have
improved clinical outcomes in pediatric patients. However, ∼40% of patients with pediatric AML …

Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy

CW Elgarten, R Aplenc - Current Opinion in Pediatrics, 2020 - journals.lww.com
Further incorporation of genomic and molecular data in pediatric AML will allow for additional
refinements in risk stratification to enable the tailoring of treatment intensity. These data will …

Outcome of pediatric acute myeloid leukemia (AML) in low-and middle-income countries: a systematic review of the literature

RE Van Weelderen, K Klein… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Survival rates of pediatric acute myeloid leukemia (AML) in low- and middle-income
countries (LMICs) seem extremely poor, and the available literature on the matter is …