What is the therapeutic mechanism of pedunculopontine nucleus stimulation in Parkinson's disease?
W Thevathasan, E Moro - Neurobiology of disease, 2019 - Elsevier
… ganglia – suggesting the PPN may influence or be influenced by higher order action selection…
no stimulation (Lim et al., 2009). Importantly, this study found that the increased REM sleep …
no stimulation (Lim et al., 2009). Importantly, this study found that the increased REM sleep …
Role of pedunculopontine nucleus in sleep-wake cycle and cognition in humans: A systematic review of DBS studies
L Ricciardi, M Sarchioto, F Morgante - Neurobiology of Disease, 2019 - Elsevier
… of REM sleep time and REM percentage when PPN-DBS was ON compared to when the
stimulation … Non-motor functions in parkinsonian patients implanted in the pedunculopontine …
stimulation … Non-motor functions in parkinsonian patients implanted in the pedunculopontine …
Pedunculopontine nucleus: an integrative view with implications on deep brain stimulation
… in movement disorders such as Parkinson's disease (PD). … rates during wakefulness and
REM sleep and the role of the … spinal cord where it might influence direct motor output. Thus, …
REM sleep and the role of the … spinal cord where it might influence direct motor output. Thus, …
[HTML][HTML] Excessive daytime sleepiness in a model of Parkinson's disease improved by low-frequency stimulation of the pedunculopontine nucleus
A Davin, S Chabardès, A Devergnas… - … Parkinson's Disease, 2023 - nature.com
… stimulation (12 h of daytime stimulation) influences … REM sleep in the parkinsonian state;
these REM episodes were abolished with PPN-LFS (Table 1a). Although the overall REM sleep …
these REM episodes were abolished with PPN-LFS (Table 1a). Although the overall REM sleep …
[HTML][HTML] Pedunculopontine nucleus degeneration contributes to both motor and non-motor symptoms of Parkinson's disease
NE Chambers, K Lanza, C Bishop - Frontiers in Pharmacology, 2020 - frontiersin.org
… Unfortunately, how PPN neuronal populations and their respective projections influence PD
… likely contributes to REM sleep atonia in PD patients. Congruent with PPN involvement in …
… likely contributes to REM sleep atonia in PD patients. Congruent with PPN involvement in …
Deep brain stimulation of the pedunculopontine tegmental nucleus and arousal in Parkinson's disease
… innervate midline thalamic nuclei, mediate REM sleep, and … -sleep stages in patients
affected by the Parkinson disease and … , thus establishing a route to influence spinal cord motor …
affected by the Parkinson disease and … , thus establishing a route to influence spinal cord motor …
[HTML][HTML] The impact of deep brain stimulation on sleep in Parkinson's disease: an update
JRP Zuzuárregui, JL Ostrem - Journal of Parkinson's disease, 2020 - content.iospress.com
… However, the percent of REM atonia relative to REM sleep was not evaluated in this … to
influence the interaction between wakefulness and sleep, with likely more impact on REM sleep …
influence the interaction between wakefulness and sleep, with likely more impact on REM sleep …
Pedunculopontine nucleus deep brain stimulation for Parkinsonian disorders: a case series
V Dayal, A Rajabian, M Jahanshahi… - Stereotactic and …, 2021 - karger.com
… PPN-DBS has also been described to improve REM sleep and cognition [14‒16]. …
Among PSP patients, another factor that may influence the degree of response to PPN …
Among PSP patients, another factor that may influence the degree of response to PPN …
The role of pedunculopontine nucleus in isolated REM sleep behavior disorder and REM sleep without atonia
… Parkinson's disease or other parkinsonism disorders with RBD, the degeneration of pontine
cholinergic nucleus … modulatory influences of several suprasegmental structures. The major …
cholinergic nucleus … modulatory influences of several suprasegmental structures. The major …
Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus
E Garcia‐Rill - Journal of neuroscience research, 2019 - Wiley Online Library
… to novel therapies such as PPN deep brain stimulation (DBS) for Parkinson’s disease (PD), …
underlying gamma activity during waking versus REM sleep, and revealed the presence of …
underlying gamma activity during waking versus REM sleep, and revealed the presence of …