What is the therapeutic mechanism of pedunculopontine nucleus stimulation in Parkinson's disease?

W Thevathasan, E Moro - Neurobiology of disease, 2019 - Elsevier
… ganglia – suggesting the PPN may influence or be influenced by higher order action selection…
no stimulation (Lim et al., 2009). Importantly, this study found that the increased REM sleep

Role of pedunculopontine nucleus in sleep-wake cycle and cognition in humans: A systematic review of DBS studies

L Ricciardi, M Sarchioto, F Morgante - Neurobiology of Disease, 2019 - Elsevier
… of REM sleep time and REM percentage when PPN-DBS was ON compared to when the
stimulation … Non-motor functions in parkinsonian patients implanted in the pedunculopontine

Pedunculopontine nucleus: an integrative view with implications on deep brain stimulation

A Nowacki, S Galati, J Ai-Schlaeppi, C Bassetti… - … of disease, 2019 - Elsevier
… in movement disorders such as Parkinson's disease (PD). … rates during wakefulness and
REM sleep and the role of the … spinal cord where it might influence direct motor output. Thus, …

[HTML][HTML] Excessive daytime sleepiness in a model of Parkinson's disease improved by low-frequency stimulation of the pedunculopontine nucleus

A Davin, S Chabardès, A Devergnas… - … Parkinson's Disease, 2023 - nature.com
stimulation (12 h of daytime stimulation) influencesREM sleep in the parkinsonian state;
these REM episodes were abolished with PPN-LFS (Table 1a). Although the overall REM sleep

[HTML][HTML] Pedunculopontine nucleus degeneration contributes to both motor and non-motor symptoms of Parkinson's disease

NE Chambers, K Lanza, C Bishop - Frontiers in Pharmacology, 2020 - frontiersin.org
… Unfortunately, how PPN neuronal populations and their respective projections influence PD
… likely contributes to REM sleep atonia in PD patients. Congruent with PPN involvement in …

Deep brain stimulation of the pedunculopontine tegmental nucleus and arousal in Parkinson's disease

P Mazzone, G Della Marca, E Scarnati - … and Psychiatric Diseases, 2019 - Elsevier
… innervate midline thalamic nuclei, mediate REM sleep, and … -sleep stages in patients
affected by the Parkinson disease and … , thus establishing a route to influence spinal cord motor …

[HTML][HTML] The impact of deep brain stimulation on sleep in Parkinson's disease: an update

JRP Zuzuárregui, JL Ostrem - Journal of Parkinson's disease, 2020 - content.iospress.com
… However, the percent of REM atonia relative to REM sleep was not evaluated in this … to
influence the interaction between wakefulness and sleep, with likely more impact on REM sleep

Pedunculopontine nucleus deep brain stimulation for Parkinsonian disorders: a case series

V Dayal, A Rajabian, M Jahanshahi… - Stereotactic and …, 2021 - karger.com
… PPN-DBS has also been described to improve REM sleep and cognition [14‒16]. …
Among PSP patients, another factor that may influence the degree of response to PPN …

The role of pedunculopontine nucleus in isolated REM sleep behavior disorder and REM sleep without atonia

D Aygün, Fİ Ertaş, A Gündüz, GB Şenel… - … & Related Disorders, 2021 - Elsevier
Parkinson's disease or other parkinsonism disorders with RBD, the degeneration of pontine
cholinergic nucleus … modulatory influences of several suprasegmental structures. The major …

Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus

E Garcia‐Rill - Journal of neuroscience research, 2019 - Wiley Online Library
… to novel therapies such as PPN deep brain stimulation (DBS) for Parkinson’s disease (PD), …
underlying gamma activity during waking versus REM sleep, and revealed the presence of …